XRCC2 Antibody
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中文名稱：XRCC2兔多克隆抗體
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貨號：CSB-PA004530
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規(guī)格：￥1090
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圖片：
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Western Blot analysis of 293 cells using XRCC2 Polyclonal Antibody
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：XRCC2
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別名：DKFZp781P0919 antibody; DNA repair protein XRCC2 antibody; X ray repair complementing defective repair in Chinese hamster cells 2 antibody; X ray repair cross complementing protein 2 antibody; X-ray repair cross-complementing protein 2 antibody; Xrcc2 antibody; XRCC2_HUMAN antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Synthesized peptide derived from the C-terminal region of Human XRCC2.
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：WB, IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:10000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.
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基因功能參考文獻(xiàn)：
- XRCC2 rs3218408 was related with increased risk of colorectal cancer. PMID: 29748531
- Results identified a significant relationship between SNP rs3218536 of XRCC2 and an increased risk of endometrial cancer development. PMID: 30194171
- Truncating variants in PALB2, ATM and CHEK2 , but not XRCC2 were associated with increased breast cancer risk. PMID: 28779002
- meta-analysis indicates that XRCC2 rs3218536 and ERCC2 rs13181 polymorphisms may not be associated with the risk of ovarian cancer PMID: 27863412
- Study has shown that most rare XRCC2 missense variants have little effect on XRCC2 protein function and are unlikely to be associated with familial and early-onset breast cancer. PMID: 27233470
- involvement of ZNF281 in the cellular response to genotoxic stress through the control exercised on the expression of genes that act in different repair mechanisms PMID: 26300006
- XRCC2 is shown to be the 20th Falconi anemia (FA) gene and is 2nd RAD51 paralog so identified. XRCC2 is required to maintain levels of other RAD51 paralogs that are normally present in XRCC2-RAD51B-C-D complex. PMID: 27208205
- Polymorphism of XRCC2 gene is associated with Nasopharyngeal Carcinoma. PMID: 27356695
- Results indicate that homologous recombination repair genes XRCC2 Arg188His and XRCC3 Thr241Met polymorphisms may be positively associated with the incidence of ovarian carcinoma in the population of Polish women. PMID: 26801223
- Suggest that XRCC2 is a useful predictive biomarker of preoperative radiotherapy treatment response in locally advanced rectal cancer patients. PMID: 26320178
- The XRCC2 Arg188His polymorphism was associated with the risk of ovarian cancer. (Meta-analysis) PMID: 26400309
- The aim of the present study was to evaluate the relationship between prostate cancer risk and the presence of single nucleotide polymorphisms in the genes involved in Homologous recombination repair, RAD51, RAD51B, XRCC2 and XRCC3. PMID: 26339569
- In conclusion, XRCC2 Arg188His and XRCC3 Thr241Met polymorphisms may be regarded as predictive factors of triple-negative breast cancer in female population. PMID: 24728564
- XRCC2 protein expression of colorectal cancer Chinese Han patients with CT/TT genotypes were significantly higher than CC genotype. PMID: 25304007
- The GA genotype of the Arg188His polymorphism of XRCC2 was associated with increased risk of breast cancer in a Pakistani cohort. PMID: 25556451
- Single nucleotide changes were studied in XRCC2 and XRCC3 genes at locus Arg188His and Thr241Met in stomach cancer patients who lived in North Eastern Turkey and in controls. PMID: 25428673
- Links the SNP -41657C/T (rs718282) of the XRCC2 gene with endometrial carcinoma in Polish women. PMID: 26017882
- Our data suggests that deregulation of XRCC2 in breast cancer has the potential to predict lymph node metastasis PMID: 25159888
- A relationship was identified between XRCC2-41657C/T polymorphism and the incidence of ovarian cancer. PMID: 25355640
- impact of XRCC2 Arg188His polymorphism on cancer susceptibility PMID: 24621646
- Interaction of tobacco and polymorphisms of XRCC1 and XRCC2 increases the risk of head and neck squamous cell carcinoma in northeast Indian population.The XRCC2 Arg188His polymorphism was associated with increased risk of this cancer. PMID: 24958516
- High XRCC2 expression promotes CRC cell proliferation and enriches cells in the G0/G1 phase but inhibits apoptosis. PMID: 25526472
- Our data suggest that the suppression of XRCC2 expression rendered colon tumor cells more sensitive to radiation therapy in vitro and in vivo. PMID: 24481064
- Genetic variants in XRCC2 are not associated with soft-tissue sarcoma. PMID: 24189466
- current meta-analysis indicated that the Arg188His polymorphism in the XRCC2 gene might be a risk factor for ovarian cancer PMID: 24414483
- Studied whether the double strand break gene polymorphisms XRCC2 R188H G>A (rs3218536), XRCC3 T241M C>T (rs861539) and R243H G>A (rs77381814) are associated with cervical cancer in Argentine women. PMID: 23539294
- Our data do not confirm an association between XRCC2 variants and breast cancer risk, although a relative risk smaller than two could not be excluded. PMID: 23054243
- polymorphisms in XRCC2 do not contribute to cancer risk in a population of Lynch syndrome patients with colorectal cancer PMID: 21974800
- The results support the hypothesis that polymorphism of XRCC2 may be associated with the incidence of sporadic breast cancer in Polish women. PMID: 22611952
- The identification of XRCC2 as a breast cancer susceptibility gene thus increases the proportion of breast cancers that are associated with homologous recombination-DNA-repair dysfunction and Fanconi anemia. PMID: 22464251
- These findings suggest that XRCC2 SNPs may influence breast cancer risk and survival. PMID: 21632523
- The Arg188His polymorphism of the XRCC2 gene can modify the risk of colorectal cancer. PMID: 21104022
- Data show that XRCC2 and other homologous recombination proteins, including the key recombinase RAD51, co-localize with the centrosome, potentially to coordinate the deployment of a DNA damage response at vulnerable phases of the cell cycle. PMID: 21276791
- the present meta-analysis suggests that the XRCC2 Arg188His is not directly associated with breast cancer risk PMID: 20127279
- An important function of XRCC2 is to enhance the activity of RAD51, so that the loss of XRCC2 results in a severe delay in the early response of RAD51 to DNA damage. PMID: 20189471
- may influence the repair capacity of breast cancer patients and, in turn, confer genetic predisposition to disease PMID: 20004634
- Homologous pairing and ring and filament structure formation activities of the human Xrcc2*Rad51D complex. PMID: 11834724
- a critical role in homologous recombination repair PMID: 14645207
- hXRCC2 enhances ADP/ATP processing and strand exchange by hRAD51 PMID: 15123651
- Finds no association between XRCC2 R188H polymorphism and risk of colorectal adenoma. PMID: 15184273
- Considering that the XRCC2 (R188H) allele reduces risk to epithelial ovarian cancer, the increased XRCC2 activity with the R188H polymorphism may have clinical benefit in preventing cancer risk. PMID: 17141189
- possible association of single nucleotide polymorphism at the 41657C/T position and 4234G/C position of XRCC2 with susceptibility to esophageal squamous cell carcinoma (ESCC) and gastric cardiac adenocarcinoma (GCA) PMID: 17922422
- polymorphism may be one of the genetic modifiers for smoking-related pancreatic cancer PMID: 17986315
- investigated the possible association of three SNPs, XRCC2 C41657T, XRCC2 G4234C and XRCC3 A17893G with susceptibility to esophageal squamous cell carcinoma and gastric cardia adenocarcinoma in a population of northern China PMID: 18046624
- Findings suggest that the heterozygous and homozygous T allele of the XRCC4 G-1394T may be associated with the development of breast cancer PMID: 18383855
- The snp XRCC2 rs3218536 showd some evidence of a protective association for the rare allele in progesterone receptor positive breast neoplasms. PMID: 19064565
- Investigation supports a role for XRCC2 in colorectal cancer tumorigenesis, conferring susceptibility to rectal tumors. PMID: 19690184
- Observational study and meta-analysis of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 19127255
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相關(guān)疾病：Fanconi anemia, complementation group U (FANCU)
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亞細(xì)胞定位：Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
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蛋白家族：RecA family, RAD51 subfamily
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