XPR1 Antibody

說明書

產品詳情

Uniprot No.：

Q9UBH6
基因名：

XPR1
別名：

FLJ90308 antibody; OTTHUMP00000033084 antibody; OTTHUMP00000033085 antibody; Polytropic murine leukamia virus receptor SYG 1 antibody; Polytropic murine leukamia virus receptor SYG1 antibody; Protein SYG1 homolog antibody; SYG 1 antibody; SYG1 antibody; SYG1 protein antibody; X-receptor antibody; X3 antibody; Xenotropic and polytropic murine leukemia virus receptor X3 antibody; Xenotropic and polytropic retrovirus receptor antibody; Xenotropic and polytropic retrovirus receptor 1 antibody; XPR 1 antibody; XPR1 antibody; XPR1 protein antibody; XPR1_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human XPR1
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Plays a role in phosphate homeostasis. Mediates phosphate export from the cell. Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules.
基因功能參考文獻：
1. These results confirm that loss of XPR1-mediated phosphate export function causes primary familial brain calcification, occurring in less than 8 % of cases negative for the other genes, and may be responsible for parkinsonism. PMID: 27230854
2. XPR1 mutations alter phosphate export and phosphate homeostasis in primary familial brain calcification. PMID: 25938945
3. These studies suggest that the expression of Xpr1 and certain genotypes of the RNASEL gene, which could restrict XMRV infection, may play important roles in defining XMRV tropisms in certain cell types. PMID: 20410264
相關疾病：

Basal ganglia calcification, idiopathic, 6 (IBGC6)
亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

SYG1 (TC 2.A.94) family
組織特異性：

Widely expressed. Detected in spleen, lymph node, thymus, leukocytes, bone marrow, heart, kidney, pancreas and skeletal muscle.
數據庫鏈接：

HGNC: 12827

OMIM: 605237

KEGG: hsa:9213

STRING: 9606.ENSP00000356562

UniGene: Hs.227656

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