XAB2 Antibody

中文名稱：

XAB2兔多克隆抗體
貨號：

CSB-PA862073LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: Hela whole cell lysate, K562 whole cell lysate, A549 whole cell lysate
All lanes: XAB2 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 101 kDa
Observed band size: 101 kDa

IHC image of CSB-PA862073LA01HU diluted at 1:400 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA862073LA01HU diluted at 1:400 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of PC-3 cells with CSB-PA862073LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) XAB2 Polyclonal antibody
Uniprot No.：

Q9HCS7
基因名：

XAB2
別名：

0610041O14Rik antibody; adapter protein ATH 55 antibody; Adapter protein ATH-55 antibody; Ath55 antibody; AV025587 antibody; Crn related protein kim1 antibody; crn-related protein kim1 antibody; DKFZp762C1015 antibody; HCNP antibody; HCNP protein antibody; HCRN antibody; KIAA1177 antibody; NTC90 antibody; PP3898 antibody; Pre-mRNA-splicing factor SYF1 antibody; Protein HCNP antibody; RNA splicing factor antibody; SYF1 antibody; SYF1 homolog antibody; SYF1 homolog, RNA splicing factor antibody; SYF1 pre mRNA splicing factor antibody; SYF1_HUMAN antibody; Xab2 antibody; XPA binding protein 2 antibody; XPA-binding protein 2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Pre-mRNA-splicing factor SYF1 protein (750-840AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，XAB2 Antibody (CSB-PA862073LA01HU)，的標記方式是Non-conjugated。對于XAB2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA862073LB01HU	XAB2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA862073LC01HU	XAB2 Antibody, FITC conjugated
Biotin	CSB-PA862073LD01HU	XAB2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:200-1:500
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in pre-mRNA splicing as component of the spliceosome. Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing.
基因功能參考文獻：
1. these results support a novel function of XAB2 in mitotic cell cycle regulation, which is partially mediated by transcription regulation on CENPE. PMID: 27735937
2. we suggest that the XAB2 complex mediates DNA damage response events important for the end resection step of homologous recombination , and speculate that its adjacent-localization relative to double-strand break marked by gH2AX is important for this function PMID: 27084940
3. Study identifies XAB2 tagSNPs (rs794078 and rs4134816) significantly associated with the risk of non-small cell lung cancer (NSCLC) in Chinese population, which supports XAB2 playing significant role in the development of NSCLC. PMID: 26228655
4. Hematopoietic myeloid cell differentiation diminishes nucleotide excision repair and XAB2 expression. PMID: 25027282
5. XAB2 complex is a multifunctional factor involved in pre-mRNA splicing, transcription, and transcription-coupled DNA repair. PMID: 17981804
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亞細胞定位：

Nucleus.
蛋白家族：

Crooked-neck family
數據庫鏈接：

HGNC: 14089

OMIM: 610850

KEGG: hsa:56949

STRING: 9606.ENSP00000351137

UniGene: Hs.9822

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