WEE2 Antibody
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中文名稱：WEE2兔多克隆抗體
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貨號(hào)：CSB-PA020181
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規(guī)格：￥1090
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：
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別名：hCG_39453 antibody; WEE1 homolog 2 (S. pombe) antibody; Wee1-like protein kinase 1B antibody; Wee1-like protein kinase 2 antibody; WEE1B antibody; Wee1B kinase antibody; Wee2 antibody; WEE2_HUMAN antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Synthesized peptide derived from the Internal region of Human Wee 2.
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:5000 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點(diǎn)詳情
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功能：Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation.
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基因功能參考文獻(xiàn)：
- homozygous mutations in WEE2 that are responsible for fertilization failure in humans, were identified. PMID: 29606300
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亞細(xì)胞定位：Nucleus.
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蛋白家族：Protein kinase superfamily, Ser/Thr protein kinase family, WEE1 subfamily
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組織特異性：Expressed in oocytes (at protein level). May also be expressed in testis.
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數(shù)據(jù)庫鏈接：
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