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WDR34 Antibody, HRP conjugated

說明書

中文名稱：

WDR34兔多克隆抗體, HRP偶聯
貨號：

CSB-PA842668LB01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) WDR34 Polyclonal antibody
Uniprot No.：

Q96EX3
基因名：

WDR34
別名：

bA216B9.3 antibody; DIC5 antibody; MGC20486 antibody; OTTHUMP00000022282 antibody; RP11 216B9.5 antibody; WD repeat containing protein 34 antibody; WD repeat domain 34 antibody; WD repeat-containing protein 34 antibody; WDR 34 antibody; Wdr34 antibody; WDR34_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human WD repeat-containing protein 34 protein (1-210AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system. DYNC2I2 plays a major role in retrograde ciliary protein trafficking and in ciliogenesis. Required also to maintain a functional transition zone.; Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation.
基因功能參考文獻：
1. In addition to the in vitro experiments, WDR34 negativity was correlated with tumoral growth of OSCCs. Our findings suggested that WDR34 inhibits OSCC progression and might be a potential tumor-suppressor molecule in OSCCs. PMID: 29278705
2. In patients with short-rib polydactyly syndrome type III, primary cilia in WDR34 mutant fibroblasts were significantly shorter than normal and had a bulbous tip. PMID: 24183449
3. Mutations in WDR34 cause Jeune asphyxiating thoracic dystrophy. WDR34 is critical for ciliary functions essential to normal development and survival. PMID: 24183451
4. Results suggest that WDR34 is a TAK1-associated inhibitor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway. PMID: 19521662
相關疾病：

Short-rib thoracic dysplasia 11 with or without polydactyly (SRTD11)
亞細胞定位：

Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium. Cell projection, filopodium.
組織特異性：

Expressed in several cell lines (at protein level).
數據庫鏈接：

HGNC: 28296

OMIM: 613363

KEGG: hsa:89891

STRING: 9606.ENSP00000361800

UniGene: Hs.495240

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