WDPCP Antibody, HRP conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) WDPCP Polyclonal antibody
Uniprot No.：

O95876
基因名：

WDPCP
別名：

Bardet-Biedl syndrome 15 protein antibody; Chromosome 2 open reading frame 86 antibody; DKFZp686C12204 antibody; Fritz antibody; FRITZ_HUMAN antibody; hFrtz antibody; WD repeat containing protein C2orf86 antibody; WD repeat-containing and planar cell polarity effector protein antibody; WD repeat-containing and planar cell polarity effector protein fritz homolog antibody; WDPCP antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human WD repeat-containing and planar cell polarity effector protein fritz homolog protein (621-737AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies.
基因功能參考文獻：
1. Inflammatory cytokines cause reduced WDPCP expression, which contributes to impaired ciliogenesis in human rhinosinusitis. PMID: 28001338
2. study linked mutations in Fritz to Bardet-Biedl and Meckel-Gruber syndromes, a notable link given that other genes mutated in these syndromes also influence collective cell movement and ciliogenesis PMID: 20671153
相關疾病：

Bardet-Biedl syndrome 15 (BBS15); Congenital heart defects, hamartomas of tongue, and polysyndactyly (CHDTHP)
亞細胞定位：

Cell membrane. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body.
蛋白家族：

WD repeat fritz family
數據庫鏈接：

HGNC: 28027

OMIM: 217085

KEGG: hsa:51057

STRING: 9606.ENSP00000272321

UniGene: Hs.414952

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