WDFY2 Antibody
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中文名稱：WDFY2兔多克隆抗體
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貨號：CSB-PA850405LA01HU
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規格：￥440
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圖片：
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Western Blot
Positive WB detected in: MCF-7 whole cell lysate
All lanes: WDFY2 antibody at 5.6µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 46 kDa
Observed band size: 46 kDa -
Immunofluorescence staining of Hela cells with CSB-PA850405LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) WDFY2 Polyclonal antibody
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Uniprot No.：
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基因名：WDFY2
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別名：PROF antibody; Propeller-FYVE protein antibody; RP11 147H23.1 antibody; WD repeat and FYVE domain containing 2 antibody; WD repeat and FYVE domain-containing protein 2 antibody; WD40 and FYVE domain containing 2 antibody; WD40- and FYVE domain-containing protein 2 antibody; WDF2 antibody; Wdfy2 antibody; WDFY2_HUMAN antibody; ZFYVE22 antibody; Zinc finger FYVE domain-containing protein 22 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human WD repeat and FYVE domain-containing protein 2 protein (2-114AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產品，WDFY2 Antibody (CSB-PA850405LA01HU)，的標記方式是Non-conjugated。對于WDFY2 Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, WB, IF
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 IF 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2. Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1. Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates. Participates in transferrin receptor endocytosis.
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基因功能參考文獻：
- Our results showed that WDFY2 inhibited cancer cell colony formation and migration via suppressing Akt pathway, making it a potential new therapeutic target in prostate cancer. PMID: 28653900
- CDKN2D-WDFY2 fusion could be an important molecular signature for understanding and classifying sub-lineages among heterogeneous high-grade serous ovarian carcinomas. PMID: 24675677
- The ProF protein partially co-localizes with EEA1 on vesicular structures and binds to the protein kinases Akt and PKCzeta/lambda (protein kinase Czeta/lambda) via its WD-repeat propeller. PMID: 16792529
- WDFY2, the WD40 and FYVE domain containing protein 2, has roles in endocytosis PMID: 16873553
- presence of ProF increases the PKCzeta-dependent phosphorylation of VAMP2 in vitro PMID: 17313651
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亞細胞定位：Endosome. Early endosome. Cytoplasm.
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數據庫鏈接：
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