VTA1 Antibody, FITC conjugated

說明書

中文名稱：

VTA1兔多克隆抗體, FITC偶聯
貨號：

CSB-PA882062LC01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) VTA1 Polyclonal antibody
Uniprot No.：

Q9NP79
基因名：

VTA1
別名：

C6orf55 antibody; Chromosome 6 open reading frame 55 antibody; Dopamine responsive protein DRG 1 antibody; Dopamine-responsive gene 1 protein antibody; DRG 1 antibody; DRG-1 antibody; DRG1 antibody; Homolog of mouse SKD1 binding protein 1 antibody; HSPC228 antibody; LIP5 antibody; LYST interacting protein 5 antibody; LYST-interacting protein 5 antibody; My012 antibody; SBP1 antibody; SKD1 binding protein 1 antibody; SKD1-binding protein 1 antibody; Vacuolar protein sorting-associated protein VTA1 homolog antibody; Vps20 associated 1 homolog (S. cerevisiae) antibody; VTA1 antibody; VTA1_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Vacuolar protein sorting-associated protein VTA1 homolog protein (23-307AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR. Involved in HIV-1 budding.
基因功能參考文獻：
1. Data suggest that AQP2 binds LIP5 in a AQP2-phosphorylation-dependent manner; phospho-mimicking mutations and phosphorylation reduce thermal stability of AQP2; AQP2 phosphorylation allosterically controls its interaction with LIP5. [AQP2 = aquaporin 2; LIP5 = LYST-interacting protein 5; LYST = lysosomal trafficking regulator protein] PMID: 28710278
2. Crystal structures of three molecular complexes reveal that IST1 binds to the MIT domains of VPS4 and LIP5. PMID: 25657007
3. the tandem MIT domain of LIP5 binds different types of ESCRT-III proteins, promoting assembly of active VPS4 enzymes on the polymeric ESCRT-III substrate. PMID: 23105106
4. LIP5 protein expression in a mouse tissue panel and various rodent and human tissues were studied. PMID: 20358264
亞細胞定位：

Cytoplasm. Endosome membrane; Peripheral membrane protein.
蛋白家族：

VTA1 family
數據庫鏈接：

HGNC: 20954

OMIM: 610902

KEGG: hsa:51534

STRING: 9606.ENSP00000356602

UniGene: Hs.431367

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