VPS36 Antibody, HRP conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) VPS36 Polyclonal antibody
Uniprot No.：

Q86VN1
基因名：

VPS36
別名：

C13orf9 antibody; CGI 145 antibody; EAP45 antibody; ELL associated protein of 45 kDa antibody; ELL-associated protein of 45 kDa antibody; ESCRT-II complex subunit VPS36 antibody; Vacuolar protein sorting associated protein 36 antibody; Vacuolar protein-sorting-associated protein 36 antibody; Vps36 antibody; VPS36_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Peptide sequence from Human Vacuolar protein-sorting-associated protein 36 protein (87-105AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.
基因功能參考文獻：
1. RAB27A, RAB27B and VPS36 are frequently underexpressed in advanced prostate cancer and are inversely correlated with prostate cancer outcome. There seems to be a close relationship in the expression of RAB27A, RAB27B and VPS36, with RAB27A and RAB27B being dependent on VPS36. PMID: 28197629
2. Crystallographic and biochemical analyses reveal that the GLUE domain of the human ESCRT-II EAP45 (also called VPS36) subunit is a split pleckstrin-homology domain that binds ubiquitin along one edge of the beta-sandwich. PMID: 17057716
亞細胞定位：

Cytoplasm. Endosome. Late endosome. Membrane. Nucleus.
蛋白家族：

VPS36 family
數據庫鏈接：

HGNC: 20312

OMIM: 610903

KEGG: hsa:51028

STRING: 9606.ENSP00000367299

UniGene: Hs.109520

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