VIP Antibody

說明書

中文名稱：

VIP兔多克隆抗體
貨號：

CSB-PA949950
規(guī)格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA949950(VIP Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA949950(VIP Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

P01282
基因名：

VIP
別名：

Peptide histidine methioninamide 27 antibody; Peptide histidine valine 42 antibody; PHM27 antibody; PHV42 antibody; Prepro VIP antibody; Vasoactive intestinal peptide antibody; Vasoactive intestinal polypeptide antibody; VIP antibody; VIP peptides antibody; VIP peptides precursor antibody; VIP_HUMAN antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Rat
免疫原：

Full length fusion protein
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.; PHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin.
基因功能參考文獻(xiàn)：
1. VIP SNPs are associated with VIP serum level and response to rheumatoid arthritis treatment. PMID: 29391448
2. this review provides an overview of VIP effects on rheumatoid arthritis pathology PMID: 30155495
3. Results have suggested that pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP), but predominantly VIP, induce neuroblastoma differentiation into benign form by regulating hypoxia-inducible factors, vascular endothelial growth factor and vascular endothelial growth factor receptor expression and distribution. PMID: 29699729
4. Results found that VIP enhanced trophoblast cell migration and invasion through the activation of high affinity VPAC receptors and PKA-CRE signaling pathways suggesting that VIP-mediated autocrine pathways regulate trophoblast cell function and contribute to immune homeostasis maintenance at placentation. PMID: 27212399
5. this study shows that that VIP exerts anti-inflammatory effects by inhibiting the MAPK-p47phox phosphorylation-NOX2 activation axis, and that VIP dampens carrageenan-induced inflammation in rats PMID: 27271317
6. Both mast cells and VIP appear to be important factors in the regulation of this bacterial translocation through the colonic mucosa of irritable bowel syndrome patients. PMID: 28711627
7. we found that VIP inhibits NFAT nuclear translocation in primary human pulmonary artery smooth muscle cells (PASMC). Early activation of NFATc3 in IPF patients may contribute to disease progression and the increase in VIP expression could be a protective compensatory mechanism PMID: 28125639
8. VIP and CRF reduce ADAMTS expression and function in osteoarthritis synovial fibroblasts. PMID: 26818776
9. optogenetically activating single VIPs in live mice while recording the activity of nearby neurons, we find that VIPs break open a hole in blanket inhibition. PMID: 27013676
10. a differential effect of VIP on the expression of TNFalpha and IL-6 receptors, since VIP was only able to decreased expression in LPS-stimulated monocytes but not in 4/74-infected monocytes. PMID: 26206287
11. VIP promotes Th17 polarization of memory Th cells in early arthritis. PMID: 25957307
12. The circadian rhythm amplitude of motor activity in both Alzheimer disease subjects and age-matched controls is correlated with the number of vasoactive intestinal peptide-expressing suprachiasmatic nucleus neurons. PMID: 25921596
13. Skin VIP expression, a marker of sudomotor innervation, was significantly lower in patients with familial transthyretin amyloid neuropathy compared to controls. PMID: 25973863
14. Alterations in VIP expression may play a role in irritable bowel syndrome. PMID: 25574088
15. Interictal CGRP and, to a lesser degree, VIP levels measured in peripheral blood are of great help in predicting response of chronic migraine patients to Onabotulinumtoxin type A PMID: 24673487
16. The antimicrobial peptide, VIP is a neuropeptide with activity against a range of microorganisms from skin, oral, respiratory and gastrointestinal tract sites. PMID: 18603306
17. VIP is significantly increased in the patients with chronic obstructive pulmonary disease and pulmonary hypertension. PMID: 24228853
18. Serum levels of vasoactive intestinal peptide as a prognostic marker in early arthritis. PMID: 24409325
19. Data suggest that two closely related neuroprotective peptides, vasoactive intestinal peptide (VIP) and pituitary adenylyl cyclase-activating peptide (PACAP), are up-regulated in neurons/immune cells after injury and/or inflammation. [REVIEW] PMID: 23517078
20. Our study suggested that baicalein exerts a positive effect on the VIP expression in HCMV-infected EVT at maternal-fetal interface. PMID: 23771668
21. VIP can inhibit the cytotoxicity of natural killer cells to MKN45 cells and can inhibit the expressions of NKG2D, DAP10, and NF-kappaB in natural killer cells. PMID: 24228003
22. The results of this study indicate a connection between elevated concentration of NPY and VIP and decreased DPP IV/CD26 activity and concentration, suggesting a potential role of these molecules in the immunomodulation of rheumatoid arthritis. PMID: 23864142
23. VIP induced expression of CCL5, one of the main chemokines involved in T cell recruitment. PMID: 24492467
24. VIP expression and its receptors' polymorphism may be important in determining susceptibility to progression from mild to severe forms of Chagas disease. PMID: 23800435
25. Expression and distribution of phosphodiesterase (PDE) type 1, known to hydrolyze both cyclic AMP and -GMP, are evaluated with VIP in the vagina where their signaling pathways are involved in control of vaginal blood flow. PMID: 23490535
26. The present study found that reduced VIP innervation in the vaginal epithelium of the perimenopausal women was correlated with the severity of pelvic organ prolapse with or without stress incontinence. PMID: 23915857
27. VIP and pituitary adenylate cyclase-activating polypeptide (PACAP) may influence the course of multiple sclerosis. PMID: 24041830
28. Either PACAP or VIP were able to recover the retinal pigment epithelial barrier hyperpermeability and the reduced transepithelial electrical resistance. PMID: 23220033
29. VIP in synovial fluid and articular cartilage is negatively associated with progressive joint damage in osteoarthritis and is a potential indictor of disease severity. PMID: 22959974
30. Confocal images and FACS demonstrated a strong association and co-localization between VIP peptide and CRTH2 molecules PMID: 23168411
31. An imbalance between vasoactive intestinal peptide and substance P production results in the reestablishment and maintenance of the inflammatory process, leading to denervation and, consequently, promoting the development of megaesophagus. PMID: 22995328
32. A set of cryosections revealed extensive colocalization of calretinin with vasoactive intestinal peptide in both surviving submucosal perikarya and mucosal nerve fibres in human chagasic submucosa and mucosa. PMID: 22555304
33. The present work was undertaken to investigate the antiproliferative potential of vasoactive intestinal peptide (VIP) exposure on non-tumoral (HK2) and tumoral (A498, cRCC) human proximal tubular epithelial cell lines. PMID: 22728770
34. Vasoactive intestinal polypeptipe and GRIN3A SNPs may be associated with cerebral palsy at age 2 in children born preterm. PMID: 22914463
35. results strongly suggest that VIP synergistically enhances TNF-alpha-stimulated IL-6 and IL-8 synthesis via activating the NF-kappa-B pathway in HK-2 cells PMID: 22207455
36. We hypothesized that VIP plays a role in the activation of parasympathetic cranial outflow during migraine attacks PMID: 22108610
37. Physical exercise stimulates production of natural anti-VIP antibodies and likely results in suppression of VIP. PMID: 22140573
38. One year after sigmoid colon vaginoplasty, VIP expression was significantly lower in the neovagina than in the intact sigmoid colon, but increased 3 years postoperatively. PMID: 21426768
39. Blood levels of vasoactive intestinal polypeptide tended to be high in patients with ankylosing spondylitis as compared with those of healthy subjects and correlated with platelet counts significantly, for the first time at the literature. PMID: 20340024
40. Results demonstrate that meibomian gland epithelial transformed cells transcribe and translate VIP and mACh receptors. PMID: 21969302
41. The VIP level of the nasal septum in the perennial allergic rhinitis patients was higher than that in the normal controls. PMID: 19685709
42. Substance P and VIP neurofibers are present in the fibroid pseudocapsule of uterine fibroids, similar to the values in the normal myometrium of a non-pregnant uterus. PMID: 21167238
43. SP, CGRP and VIP may play important roles in the pathophysiological mechanism of vasomotor rhinitis. PMID: 17087112
44. SP levels are higher in repeat cesarean section, while the VIP levels are reduced in the lower uterine segment. PMID: 20692311
45. VIP increases its own intracellular and extracellular levels, and could be involved in the regulation of VPAC(1)-receptor traffic from the plasma membrane to the nucleus. PMID: 20691743
46. Data show that 1/3 of pediatric slow-transit constipation patients have low substance P or vasoactive intestinal peptide nerve fiber density in proximal colon. PMID: 20529207
47. Data describe neurons and nerve fibers of intestinal plexuses containing vasoactive intestinal peptide, pituitary adenylate cyclase-activating polypeptide and neuropeptide Y in pathologically changed parts of the large intestine in intestinal cancer. PMID: 20675276
48. Data show that TG2-L and TG2-S enhanced neuroblastoma cell differentiation due to N-Myc small interfering RNA, and suppression of vasoactive intestinal peptide (VIP) expression alone induced neuroblastoma cell differentiation. PMID: 20007697
49. Besides their presence and functions in the gut and the brain VIP and PACAP have distinct physiological roles in the genital tract. PMID: 11713978
50. Circulating VIP in fulminant hepatic failure seems to reflect hemodynamic changes in the systemic rather than in the cerebral circulation. PMID: 11884208
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亞細(xì)胞定位：

Secreted.
蛋白家族：

Glucagon family
數(shù)據(jù)庫鏈接：

HGNC: 12693

OMIM: 192320

KEGG: hsa:7432

STRING: 9606.ENSP00000356213

UniGene: Hs.53973

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