USP16 Antibody

說明書

中文名稱：

USP16兔多克隆抗體
貨號：

CSB-PA006653
規格：

￥1090
圖片：
Western Blot analysis of 3T3 cells using USP16 Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9Y5T5
基因名：

USP16
別名：

Deubiquitinating enzyme 16 antibody; Human ubiquitin processing protease antibody; MSTP039 antibody; Ubiquitin carboxyl-terminal hydrolase 16 antibody; Ubiquitin Specific peptidase 16 antibody; Ubiquitin Specific Protease 16 antibody; Ubiquitin thiolesterase 16 antibody; Ubiquitin-processing protease UBP-M antibody; Ubiquitin-specific-processing protease 16 antibody; UBP M antibody; UBP16_HUMAN antibody; UBPM antibody; usp16 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human USP16.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:10000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
基因功能參考文獻：
1. USP16 was frequently downregulated. PMID: 27633997
2. USP16 and TTC3 were dysregulated in all affected human cells and two mouse models of Down syndrome. PMID: 27586445
3. The data unveil a unique mechanism by which Usp16 promotes the localization and maintenance of Plk1 on the kinetochores for proper chromosome alignment. PMID: 26323689
4. Data show that histone H2A deubiquitinase USP16 interacts with E3 ubiquitin-protein ligase HERC2, negatively regulates DNA damage-induced ubiquitin foci formation, and is required for termination of the ubiquitin signal. PMID: 25305019
5. S552P disrupts the interaction between Ubp-M and nuclear export protein CRM1, increasing Ubp-M nuclear retention as cells progress into M phase, revealing a critical function for Ubp-M S552P. PMID: 24013421
6. in human tissues overexpression of USP16 reduces the expansion of normal fibroblasts and postnatal neural progenitors, whereas downregulation of USP16 partially rescues the proliferation defects of Down's syndrome fibroblasts PMID: 24025767
7. Study reports the solution structure of the BUZ domain of Ubp-M, a ubiquitin-specific protease, and its interaction with ubiquitin; the Ubp-M BUZ domain features three zinc-binding sites consisting of 12 residues. PMID: 17512543
8. knockdown of Ubp-M in HeLa cells results in slow cell growth rates owing to defects in the mitotic phase of the cell cycle PMID: 17914355
9. a new cryptic USP16-RUNX1 fusion in chronic myelomonocytic leukemia PMID: 18925961
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相關疾病：

A chromosomal aberration involving USP16 is a cause of Chronic myelomonocytic leukemia. Inversion inv(21) (q21;q22) with RUNX1/AML1.
亞細胞定位：

Nucleus.
蛋白家族：

Peptidase C19 family, USP16 subfamily
組織特異性：

Present in all the tissues examined including fetal brain, lung, liver, kidney, and adult heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
數據庫鏈接：

HGNC: 12614

OMIM: 604735

KEGG: hsa:10600

STRING: 9606.ENSP00000334808

UniGene: Hs.99819

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