UQCRFS1 Antibody

說明書

中文名稱：

UQCRFS1兔多克隆抗體
貨號：

CSB-PA025669GA01HU
規(guī)格：

￥3,900
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

P47985
基因名：

UQCRFS1
別名：

Complex III subunit 5 antibody; Complex III subunit IX antibody; Cytochrome b c1 complex subunit Rieske mitochondrial antibody; Cytochrome b-c1 complex subunit 11 antibody; Cytochrome b-c1 complex subunit 5 antibody; Cytochrome b6f complex iron sulfur subunit, chloroplastic antibody; petC antibody; PGR1 antibody; Plastohydroquinone:plastocyanin oxidoreductase iron sulfur protein antibody; Proton gradient regulation protein 1 antibody; Rieske iron sulfur protein antibody; Rieske iron-sulfur protein antibody; RIP1 antibody; RIS1 antibody; RISP antibody; Ubiquinol cytochrome C reductase rieske iron sulphur antibody; Ubiquinol cytochrome c reductase Rieske iron-sulfur polypeptide 1 antibody; Ubiquinol-cytochrome c reductase 8 kDa protein antibody; Ubiquinol-cytochrome c reductase iron-sulfur subunit antibody; UCRI_HUMAN antibody; UQCR5 antibody; UQCRFS1 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Human UQCRFS1
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. The Rieske protein is a catalytic core subunit containing a Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII). UQCRFS1 undergoes proteolytic processing once it is incorporated in the complex III dimer. One of the fragments, called subunit 9, corresponds to its mitochondrial targeting sequence (MTS). The proteolytic processing is necessary for the correct insertion of UQCRFS1 in the complex III dimer, but the persistence of UQCRFS1-derived fragments may prevent newly imported UQCRFS1 to be processed and assembled into complex III and is detrimental for the complex III structure and function.
基因功能參考文獻：
1. UQCRFS1 produces N-terminal polypeptides, which remain bound to holocomplex III. We show that, in normal conditions, these UQCRFS1 fragments are rapidly removed, but when TTC19 is absent they accumulate within complex III, causing its structural and functional impairment. PMID: 28673544
2. UQCRFS1/RISP knockdown in breast tumor cell line led to decreased mitochondrial membrane potential as well as a decrease in matrigel invasion. PMID: 21901141
3. UQCRFS1 gene appears to be involved in development of more aggressive phenotype of breast cancer. PMID: 15047214
亞細胞定位：

Mitochondrion inner membrane; Single-pass membrane protein.
數(shù)據(jù)庫鏈接：

HGNC: 12587

OMIM: 191327

KEGG: hsa:7386

STRING: 9606.ENSP00000306397

UniGene: Hs.743307

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