UNC5C Antibody
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中文名稱：UNC5C兔多克隆抗體
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貨號：CSB-PA025630GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：UNC5C
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別名：homolog of C. elegans transmembrane receptor Unc5 antibody; Netrin receptor UNC5C antibody; Protein unc 5 homolog C antibody; Protein unc-5 homolog 3 antibody; Protein unc-5 homolog C antibody; Unc 5 homolog 3 antibody; Unc 5 homolog C antibody; Unc5 (C.elegans homolog) c antibody; Unc5c antibody; UNC5C_HUMAN antibody; UNC5H3 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human UNC5C-Specific
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion. Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC. Also involved in corticospinal tract axon guidance independently of DCC. Involved in dorsal root ganglion axon projection towards the spinal cord. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
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基因功能參考文獻：
- Promoter Hypermethylation of UNC5C Gene is associated with Colorectal Cancer. PMID: 29801399
- The objective of this study is to investigate the influence of UNC5C loci on the neuroimaging of strategic regions of Alzheimer's disease. PMID: 26660111
- the results suggest that UNC5C methylation may be an earlier event in the development of colorectal cancer, which was negatively correlated with protein expression. PMID: 28378635
- 7 of these 8 variants do not cause increased colorectal cancer risk, including UNC5C c.1882_1883delinsAA (p.A628K). PMID: 26852919
- Data show that overexpression of wild-type netrin receptor UNC5C (UNC5C) causes low-grade death, which is intensified by an Alzheimer Disease-linked mutation T835M, and mediated by amyloid beta precursor protein (APP). PMID: 27068745
- identify the V-2 domain of netrin-1 to be important for its interaction with the Ig1/Ig2 domains of UNC5H2 PMID: 26859457
- we have identified novel frequent somatic mutations of UNC5C in muscle-invasive bladder cancers. PMID: 25316812
- T835M (rs137875858) in the UNC5C was associated with late-onset Alzheimer disease and increased cell death in HEK293 cells. PMID: 25419706
- The rare coding variant might not play an important role in AD risk in mainland China. PMID: 24866402
- UNC5C mutations are very rare in familial and sporadic colorectal carcinomas. PMID: 24415873
- TNM stage 1 hepatocellular carcinoma (HCC) presented UNC5C methylation, indicating that the UNC5C gene has been methylated from the early stages of HCC. PMID: 23178624
- knockdown of DSCAM inhibits netrin-induced tyrosine phosphorylation of UNC5C and Fyn as well as the interaction of UNC5C with Fyn. The double knockdown of both receptors abolishes the induction of Fyn tyrosine phosphorylation by netrin-1 PMID: 22685302
- Inherited mutations in UNC5C prevent apoptosis and increase risk of colorectal cancer. PMID: 21893118
- UNC5C acts as a tumour suppressor in RCC and is down-regulated in RCC. Loss of heterozygosity and DNA methylation contribute to the inactivation of UNC5C in renal cell carcinoma. PMID: 21600761
- UNC5C methylation was observed in the course of gastric carcinogenesis and disappeared in highly advanced gastric carcinomas. PMID: 20032384
- may represent tumor suppressor that inhibit tumor extension outside the region of netrin-1 availability by inducing apoptosis PMID: 12655055
- Netrin binds through multiple domains to both DCC and Unc5c. in Caenorhabditis elegans indicate that both netrin binding and nonbinding domains are necessary for phenotypic rescue of an unc-5 loss of function mutation. PMID: 15574733
- Data suggest a model in which netrin stimulates UNC5 tyrosine phosphorylation and signaling in a manner dependent on the co-receptor DCC, through the recruitment of Src and FAK kinases. PMID: 16371650
- The loss of UNC5C expression observed in human colorectal cancer is a selective advantage for tumor progression PMID: 17967459
- study provides evidence that most colorectal cancers have alterations in both UNC5C and DCC netrin receptors; while UNC5C expression is regulated primarily via epigenetic regulation, DCC defects are mediated through allelic deletions PMID: 18054557
- Aberrant methylation of the netrin-1 receptor genes UNC5C and DCC detected in advanced colorectal cancer. PMID: 19242752
- UNC5C might act as a tumor suppressor and UNC5C methylation might present a malignant potential in colorectal cancer. PMID: 19331160
- Stronger expression of UNC5B and UNC5C receptors in synovial fibroblasts might contribute to the disordered phenotype of rheumatoid arthritis and osteoarthritis. PMID: 19822088
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亞細胞定位：Cell membrane; Single-pass type I membrane protein. Cell surface. Cell junction, synapse, synaptosome. Cell projection, axon. Cell projection, dendrite. Cell projection, growth cone. Cell projection, lamellipodium. Cell projection, filopodium.
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蛋白家族：Unc-5 family
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組織特異性：Mainly expressed in brain. Expressed in temporal lobe cortical neurons and in neurons of the hippocampal pyramidal layer. Also expressed in kidney. Not expressed in developing or adult lung.
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數據庫鏈接：
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