UHMK1 Antibody, HRP conjugated

說明書

中文名稱：

UHMK1兔多克隆抗體, HRP偶聯
貨號：

CSB-PA840554LB01HU
規格：

￥880
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) UHMK1 Polyclonal antibody
Uniprot No.：

Q8TAS1
基因名：

UHMK1
別名：

DKFZp434C1613 antibody; FLJ23015 antibody; kinase interacting with leukemia-associated gene (stathmin) antibody; Kinase interacting with stathmin antibody; KIS antibody; KIS protein kinase antibody; KIST antibody; OTTHUMP00000029529 antibody; P-CIP2 antibody; Serine threonine protein kinase Kist antibody; Serine/threonine-protein kinase Kist antibody; U2AF homology motif (UHM) kinase 1 antibody; U2AF homology motif kinase 1 antibody; UHMK1 antibody; UHMK1_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Serine/threonine-protein kinase Kist protein (183-385AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA.
基因功能參考文獻：
1. UHMK1 plays a role in hematopoietic cell differentiation and suppression of autonomous clonal growth of leukemia cells. PMID: 29307747
2. genome-wide association study identified the UHMK1 gene as a novel bone mineral density locus specific to East Asians. PMID: 27424934
3. The contribution of UHMK1 gene in schizophrenia susceptibility, was explored. PMID: 21399567
4. We identify the kinase responsible for S10 phosphorylation as human kinase interacting stathmin (hKIS) and show that it regulates cell cycle progression in response to mitogens. PMID: 12093740
5. KIS gene was overexpressed in NF1-associated plexiform neurofibromas and malignant peripheral nerve sheath tumors (MPNSTs) as compared to dermal neurofibroma which suggests a possible implication of KIS in the genesis of NF1-associated tumors. PMID: 12782393
6. These results provide preliminary evidence that the UHMK1 gene increases susceptibility to schizophrenia. Further confirmation in adequately powered samples is needed. PMID: 16978587
7. KIS promoter is activated by serum-responsive GABP binding to Ets-binding sites which leads to KIS gene expression, cell migration, and cell cycle progression PMID: 17726090
8. Results show that KIS is a direct transcriptional target of FoxM1. PMID: 17984092
9. Overexpression of KIS protein kinase is associated with acute myelogenous leukemia, myelodysplastic syndrome and acute lymphoblastic leukemia PMID: 18384876
10. The association between UHMK1 and schizophrenia is confirmed. PMID: 18414510
11. KIS is expressed in neurons, and its encoded protein is localised to the nucleus and cytoplasm. No difference in KIS expression was found between schizophrenics and controls or in the lymphoblast cell lines. PMID: 19747464
12. A follow up article showing further association between markers in UHMK1 and schizophrenia in a London based sample. Association replicated in an independent Scottish sample. PMID: 18414510
13. Evidence indicating that UHMK1 may be a candidate susceptibility gene for Schizophrenia in the British population. UHMK1 is situated between previously implicated genes RGS4 and NOS1AP. PMID: 16978587
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亞細胞定位：

Nucleus.
蛋白家族：

Protein kinase superfamily, Ser/Thr protein kinase family
組織特異性：

Widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes.
數據庫鏈接：

HGNC: 19683

OMIM: 608849

KEGG: hsa:127933

STRING: 9606.ENSP00000420270

UniGene: Hs.127310

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