UGT2B4 Antibody

中文名稱：

UGT2B4兔多克隆抗體
貨號：

CSB-PA025597LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA025597LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA025597LA01HU at dilution of 1:100
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) UGT2B4 Polyclonal antibody
Uniprot No.：

P06133
基因名：

UGT2B4
別名：

UGT2B4 antibody; UGT2B11 antibody; UDP-glucuronosyltransferase 2B4 antibody; UDPGT 2B4 antibody; EC 2.4.1.17 antibody; HLUG25 antibody; Hyodeoxycholic acid-specific UDPGT antibody; UDPGTh-1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human UDP-glucuronosyltransferase 2B4 protein (281-481AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，UGT2B4 Antibody (CSB-PA025597LA01HU)，的標記方式是Non-conjugated。對于UGT2B4 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA025597LB01HU	UGT2B4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA025597LC01HU	UGT2B4 Antibody, FITC conjugated
Biotin	CSB-PA025597LD01HU	UGT2B4 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of the endogenous estrogen hormones such as estradiol and estriol.
基因功能參考文獻：
1. Clopidogrel carboxylic acid is metabolized mainly by UGT2B7 and UGT2B4 in the liver and by UGT2B17 in the small intestinal wall. PMID: 29138287
2. UGT2B4 previously implicated in the risk of breast cancer is associated with menarche timing in Ukrainian females. PMID: 27282283
3. These data indicate that knocking down PAPSS increases UGT2B4 transcription and mRNA stability as a compensatory response to the loss of SULT2A1 activity PMID: 25948711
4. Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo PMID: 22092298
5. The UGT1A8 and UGT2B4 genotypes associated with decreased predicted enzyme activities, were significantly associated with an increased risk of esophageal squamous cell carcinoma. PMID: 22367021
6. The variation pattern upstream UGT2B4 is highly unusual and may be the result of balancing selection. PMID: 21660508
7. Extensive splicing of transcripts of the bile acid-conjugating enzyme UGT2B4 modulates glucuronidation. PMID: 20139797
8. Farnesoid X receptor (FXR) induces the UGT2B4 enzyme in hepatocytes; this study identifies UGT2B4 as a novel FXR target gene. PMID: 12806625
9. UGT2B4 expression is regulated by PPARalpha PMID: 12810707
10. P.1053: "...UGT2B4...is...fairly common in Caucasians...and Africans..."but...still rare in ...Japanese..." P.1054: "...genotyping UGT2B4...in Japanese...would be useful for studies on... association between haplotypes and pharmacokinetic...parameters." PMID: 15319348
11. Results strongly indicated that the presence of an aromatic residue at position 33 is important for the activity and specificity of UGTB4. PMID: 17263731
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亞細胞定位：

Endoplasmic reticulum membrane; Single-pass membrane protein.
蛋白家族：

UDP-glycosyltransferase family
數據庫鏈接：

HGNC: 12553

OMIM: 600067

KEGG: hsa:7363

STRING: 9606.ENSP00000305221

UniGene: Hs.285887

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