UBR2 Antibody

中文名稱：

UBR2兔多克隆抗體
貨號：

CSB-PA809001LA01HU
規格：

￥440
圖片：
Western Blot
All lanes: UBR2 antibody at 3µg/ml + Mouse liver tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 201, 50, 67 kDa
Observed band size: 201 kDa
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) UBR2 Polyclonal antibody
Uniprot No.：

Q8IWV8
基因名：

UBR2
別名：

UBR2 antibody; C6orf133 antibody; KIAA0349 antibody; E3 ubiquitin-protein ligase UBR2 antibody; EC 2.3.2.27 antibody; N-recognin-2 antibody; RING-type E3 ubiquitin transferase UBR2 antibody; Ubiquitin-protein ligase E3-alpha-2 antibody; Ubiquitin-protein ligase E3-alpha-II antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human E3 ubiquitin-protein ligase UBR2 protein (101-439AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，UBR2 Antibody (CSB-PA809001LA01HU)，的標記方式是Non-conjugated。對于UBR2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA809001LB01HU	UBR2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA809001LC01HU	UBR2 Antibody, FITC conjugated
Biotin	CSB-PA809001LD01HU	UBR2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. Required for spermatogenesis, promotes, with Tex19.1, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis. Polyubiquitinates LINE-1 retrotransposon encoded, LIRE1, which induces degradation, inhibiting LINE-1 retrotransposon mobilization. Catalyzes ubiquitination and degradation of the N-terminal part of NLRP1 following NLRP1 activation by pathogens and other damage-associated signals: ubiquitination promotes degradation of the N-terminal part and subsequent release of the cleaved C-terminal part of NLRP1, which polymerizes and forms the NLRP1 inflammasome followed by host cell pyroptosis.
基因功能參考文獻：
1. There was a significant difference between the oligospermia men (oligospermia group) and the fertile men (control group) observed in this research that could indicate that the combined AT-TC-CC genotype in the UBR2 gene (rs16895863, rs373341, rs3749897 respectively) is a possible risk of idiopathic oligospermia for men in Sichuan, China. PMID: 26940145
2. The c.1,066A>T variant in the UBR2 gene is associated with increased susceptibility to azoospermia caused by meiotic arrest. PMID: 21573678
3. Study provides functional data for the mouse ubiquitin protein ligase E3 component n-recognin 2 protein. PMID: 14585983
亞細胞定位：

Nucleus. Chromosome.
蛋白家族：

UBR1 family
組織特異性：

Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level).
數據庫鏈接：

HGNC: 21289

OMIM: 609134

KEGG: hsa:23304

STRING: 9606.ENSP00000361990

UniGene: Hs.529925

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