UBE2V2 Antibody

中文名稱：

UBE2V2兔多克隆抗體
貨號：

CSB-PA025484DA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: HL60 whole cell lysate, K562 whole cell lyaste, Mouse brain tissue, Rat brain tissue
All lanes: UBE2V2 antibody at 1.5µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 17 kDa
Observed band size: 17 kDa

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA025484DA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA025484DA01HU at dilution of 1:100
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) UBE2V2 Polyclonal antibody
Uniprot No.：

Q15819
基因名：

UBE2V2
別名：

1 alpha 25 dihydroxyvitamin D3 inducible antibody; DDVit 1 antibody; DDVIT1 antibody; EDAF-1 antibody; EDAF1 antibody; EDPF-1 antibody; EDPF1 antibody; Enterocyte differentiation associated factor EDAF 1 antibody; Enterocyte differentiation promoting factor antibody; Enterocyte differentiation-associated factor 1 antibody; Enterocyte differentiation-promoting factor 1 antibody; Methyl methanesulfonate sensitive 2 antibody; MMS 2 antibody; MMS2 antibody; MMS2 homolog antibody; UB2V2_HUMAN antibody; UBE2V 2 antibody; UBE2V2 antibody; Ubiquitin conjugating enzyme E2 variant 2 antibody; Ubiquitin conjugating enzyme E2v2 antibody; Ubiquitin-conjugating enzyme E2 variant 2 antibody; UEV 2 antibody; UEV2 antibody; Vitamin D3 inducible protein antibody; Vitamin D3-inducible protein antibody
宿主：

Rabbit
反應種屬：

Human, Mouse, Rat
免疫原：

Recombinant Human Ubiquitin-conjugating enzyme E2 variant 2 protein (2-145AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，UBE2V2 Antibody (CSB-PA025484DA01HU)，的標記方式是Non-conjugated。對于UBE2V2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA025484DB01HU	UBE2V2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA025484DC01HU	UBE2V2 Antibody, FITC conjugated
Biotin	CSB-PA025484DD01HU	UBE2V2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
基因功能參考文獻：
1. Functional analysis of selected regulated proteins revealed that knockdown of HNRPD, PHB2 and UB2V2 can increase HCMV replication, while knockdown of A4 and KSRP resulted in decreased HCMV replication. PMID: 25910425
2. suppression of hMMS2 reverses L-OHP tolerance in differentiated human colorectal carcinoma cells by promoting apoptosis PMID: 24846979
3. UBE2v2 signalling through PCNA ubiquitination is not required for immunoglobulin diversification in DT40 cells. PMID: 15725630
4. Insight into the influence of protein dynamics on the affinity of ubiquitin for Mms2. PMID: 15952783
5. Mms2 physical association with ubiquitin is correlated with its ability to promote Lys63-linked ubiquitin chain assembly PMID: 17964296
6. These results point to a high level of redundancy in the DNA damage tolerance pathway and suggest the existence of another hMMS2 variant (hMMSv) or complex that can compensate for its loss. PMID: 18284681
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蛋白家族：

Ubiquitin-conjugating enzyme family
組織特異性：

Detected in placenta, colon, liver and skin. Detected at very low levels in most tissues.
數據庫鏈接：

HGNC: 12495

OMIM: 603001

KEGG: hsa:7336

STRING: 9606.ENSP00000428209

UniGene: Hs.491695

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