UBE2V1 Antibody
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中文名稱：UBE2V1兔多克隆抗體
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貨號：CSB-PA025482LA01HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA025482LA01HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) UBE2V1 Polyclonal antibody
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Uniprot No.：
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基因名：UBE2V1
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別名：CIR1 antibody; CROC-1 antibody; CROC1 antibody; CROC1A antibody; TRAF6-regulated IKK activator 1 beta Uev1A antibody; UB2V1_HUMAN antibody; UBE2V 1 antibody; UBE2V antibody; UBE2V1 antibody; Ubiquitin conjugating enzyme E2 variant 1 antibody; Ubiquitin-conjugating enzyme E2 variant 1 antibody; UEV-1 antibody; UEV1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Ubiquitin-conjugating enzyme E2 variant 1 protein (2-147AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產品，UBE2V1 Antibody (CSB-PA025482LA01HU)，的標記方式是Non-conjugated。對于UBE2V1 Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UBE2N, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production. UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway.
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基因功能參考文獻：
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20677014
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亞細胞定位：Nucleus. Note=Excluded from the nucleolus.
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蛋白家族：Ubiquitin-conjugating enzyme family
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組織特異性：Highly expressed in thyroid, pancreas, spinal cord, lymph node, trachea, adrenal gland, bone marrow and pancreas. Detected at low levels in heart, breast, placenta, brain, liver, kidney, stomach and lung.
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數據庫鏈接：
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