UBASH3B Antibody
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中文名稱：UBASH3B兔多克隆抗體
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貨號：CSB-PA840585ESR2HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA840585ESR2HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA840585ESR2HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) UBASH3B Polyclonal antibody
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Uniprot No.：
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基因名：UBASH3B
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別名：Cbl interacting protein p70 antibody; Cbl interacting protein Sts 1 antibody; Cbl interacting protein Sts1 antibody; Cbl-interacting protein p70 antibody; KIAA1959 antibody; MGC15437 antibody; Nm23 phosphorylated unknown substrate antibody; p70 antibody; SH3 domain containing 70 kDa protein antibody; Sts 1 antibody; STS-1 antibody; STS1 antibody; Suppressor of T cell receptor signaling 1 antibody; Suppressor of T-cell receptor signaling 1 antibody; T-cell ubiquitin ligand 2 antibody; TULA-2 antibody; Tyrosine-protein phosphatase STS1/TULA2 antibody; Ubash3b antibody; Ubiquitin associated and SH3 domain containing B antibody; Ubiquitin-associated and SH3 domain-containing protein B antibody; UBS3B_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Ubiquitin-associated and SH3 domain-containing protein B protein (1-300AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.
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基因功能參考文獻：
- Data suggest that Sts1 (suppressor of T-cell receptor signaling-1) negatively regulates TCR (T-cell receptor) signaling in activated T-lymphocytes via dephosphorylation of ZAP70. PMID: 24256567
- The results show that the interaction between STS-1 and ShcA is regulated in response to EGF receptor activation. PMID: 28690151
- The study reveals a role of CBL in restricting myeloid proliferation of human AML1-ETOinduced leukemia, and identifies UBASH3B as a potential target for pharmaceutical intervention. PMID: 26449661
- targeting Aurora B to microtubules by UBASH3B is necessary for the timing and fidelity of chromosome segregation in human cells PMID: 26766443
- These results show that TULA-2 is a target of miR-148a-3p PMID: 26516227
- This recovery involves the phosphorylation of p70 independent of mTOR. PMID: 25271148
- results demonstrate the importance of STS-1 in regulating IFN-alpha-induced autophagy in B cells PMID: 25959715
- UBASH3B is a functional target of anti-invasive microRNA200a that is down-regulated in triple negative breast cancer. Importantly, the oncogenic potential of UBASH3B is dependent on its tyrosine phosphatase activity. PMID: 23784775
- Ablation of TULA-2 resulted in hyperphosphorylation of Syk and its downstream effector phospholipase C-gamma2 as well as enhanced GPVI-mediated platelet functional responses. PMID: 20585042
- hsp70 inhibits apoptosis upstream and downstream of the mitochondria and is a promising therapeutic target for reversing drug-resistance in chronic myeloid leukemia-blast crisis and acute myeloid leukemia cells. PMID: 15388581
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亞細胞定位：Cytoplasm. Nucleus.
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數據庫鏈接：
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