TYMP Antibody
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中文名稱：TYMP兔多克隆抗體
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貨號：CSB-PA005681
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規格：￥1090
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圖片：
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Western Blot analysis of MCF-7, 293 cells using PD-ECGF Polyclonal Antibody.
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其他：
產品詳情
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Uniprot No.：
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基因名：TYMP
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別名：ECGF 1 antibody; ECGF antibody; ECGF1 antibody; Endothelial cell growth factor 1 antibody; Endothelial cell growth factor 1 platelet derived antibody; Endothelial cell growth factor, platelet-derived antibody; Gliostatin antibody; hPD ECGF antibody; MEDPS1 antibody; MNGIE antibody; MTDPS1 antibody; PD ECGF antibody; PD-ECGF antibody; PDECGF antibody; PDEGF antibody; Platelet derived endothelial cell growth factor antibody; Platelet derived endothelial growth factor antibody; Platelet-derived endothelial cell growth factor antibody; TdRPase antibody; Thymidine phosphorylase antibody; TP antibody; Tymp antibody; TYPH_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from the N-terminal region of Human PD-ECGF.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:20000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
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基因功能參考文獻：
- Data show that thymidine phosphorylase (TYMP) positive patients had higher systemic immune-inflammation index (SII) score. PMID: 27283904
- Investigated the contribution of myeloma-expressed thymidine phosphorylase (TP) to bone lesions. In osteoblast progenitors, TP up-regulated the methylation of RUNX2 and osterix, leading to decreased bone formation. In osteoclast progenitors, TP up-regulated the methylation of IRF8, leading to increased bone resorption. PMID: 27559096
- TP(thymidine phosphorylase ) curbed the expression of three proteins-IRF8, RUNX2, and osterix. This downregulation was epigenetically driven: High levels of 2DDR, a product of TP secreted by myeloma cells, activated PI3K/AKT signaling and increased the methyltransferase DNMT3A's expression PMID: 27658717
- TP expression is associated with tumor stage, histological grade and thrombocytosis in patients with renal cell carcinoma PMID: 27532673
- Studied the role of thymidine phosphorylase (TP) in promoting the invasion and metastasis of hepatocellular carcinoma (HCC). It was shown that TP correlated with MMP2 and MMP9 expression, and that TP mediated the migration of tumor cells through activity of MMPs in HCC cell lines. PMID: 28530649
- High VEGF expression was subsequently correlated with a short overall survival rate for patients exhibiting lymph node metastasis (P=0.0128); however, there was no significant difference in overall survival rate regarding the expression levels of TP and CD34 PMID: 26676225
- Pretreatment expression of thymidine phosphorylase/HIF-1alpha were found to predict pathologic response and outcomes in clinical stage II/III rectal cancer receiving neoadjuvant chemoradiotherapy. PMID: 26617778
- Gastrointestinal cancer patient carriers of the thymidine phosphorylase rs11479 T allele, with a low platelet count, could be at risk of a poor outcome. PMID: 25027354
- 4-methylumbelliferone exerts its antitumor effect on ovarian cancer through suppressing thymidine phosphorylase expression. PMID: 25304388
- action of thymidine phosphorylase in non-small cell lung cancer: crosstalk with Nrf2 and HO-1 PMID: 24819505
- These results demonstrate that the use of AAV to direct TYMP expression in liver is feasible as a potentially safe gene therapy strategy for Mitochondrial neurogastrointestinal encephalomyopathy. PMID: 24448160
- thymidine phosphorylase could strongly influence gastric cancer progression via the dual activities of angiogenesis and lymphangiogenesis PMID: 24798152
- We suggest that a chip including DPYD, TYMS, TYMP, TK1, and TK2 genes is a potential tool to predict response in LARC following fluoropyrimidine-based CCRT PMID: 24455740
- our study shows that IFN-alpha enhanced 5'-DFUR-induced apoptosis in gastric cancer cells by upregulation of TP expression, which is partially regulated by activation of ERK signaling PMID: 24027750
- Case Report: thymidine phosphorylase deficiency is a multisystem and ultimately fatal disease. PMID: 20151198
- thymidine phosphorylase is more likely expressed by malignant B cells in higher-grade lymphomas PMID: 24617035
- the first evidence of the significant impact of the TYMP genotype upon the clinical outcome of patients treated with HLA-identical sibling allo-SCT. PMID: 23813863
- The expressions of PD-ECGF and VEGF are higher in the colorectal carcinoma patients with schistosomiasis than in the colorectal carcinoma patients without schistosomiasis. PMID: 24024441
- These findings suggest that thymidine phosphorylase plays an important role in angiogenesis, extracellular matrix remodeling and in the prognosis of patients with colorectal cancer PMID: 23160694
- Sp1 binding sites in the gliostatin (GLS)promoter are essential for GLS mRNA expression. PMID: 22534375
- Thymidine phosphorylase induced STAT3 phosphorylation and increased total amount of unphosphorylated-STAT3 in vascular smooth muscle cells (VSMC), which may play a critical role in inhibiting VSMC proliferation PMID: 22668509
- A report of two brothers in whom novel TYMP gene mutations (c.215-13_215delinsGCGTGA; c.1159 2T > A) were associated with different clinical presentations and outcomes. PMID: 22618301
- PD-ECGF and VEGF have a synergetic effect in the proliferation of micro-vessels, and they play an important role in the proliferation and involution of hemangioma. PMID: 21837996
- The enzymatic activity of thymidine phosphorylase was required for the enhanced expression of IL-8 in human cancer cells. PMID: 22751949
- TP gene expression levels in primary CRC tissues and the primary tumor site may be useful predictors of the efficacy of oral UFT/LV chemotherapy. PMID: 22752215
- Data indicate that high thymidine phosphorylase (TP) tumor gene expression was associated with obtaining pathological complete response (pCR). PMID: 22610353
- Elevated cytoplasmic hnRNP K and TP overexpression are associated with poorer survival in oral squamous cell carcinoma patients PMID: 22321252
- High TP/PD-ECGF expression and thrombocytosis can be regarded as valuable tools for predicting overall survival in patients with gastric carcinoma. PMID: 22595739
- The expression of PD-ECGF may play an important role in the development and invasion of renal cell carcinoma. PMID: 22340655
- In Chinese advanced gastric cancer, Thymidine Phosphorylase positive & beta-tubulin III negative might predict response and prognosis to capecitabine plus paclitaxel chemotherapy. PMID: 21586171
- In grade 3 samples of CIN (Cervical Intraepithalial Neoplasia), expression of TP (separately or in combination with Ki-67 antigen) appeared to be related to imminent progression to invasive cancer. TP levels were shown to correlate directly with CIN grade PMID: 21809665
- Thymidine phosphorylase involvement in the enhancement of IgE production PMID: 21252618
- A significant correlation was noticed between HIF-1alpha and vascular endothelial growth factor expression while the expression levels of thymidine phosphorylase, cyclooxygenase and microvessel density were significantly higher in high HIF-2alpha tumors. PMID: 21362301
- Both TP and MK are important for angiogenesis in laryngeal squamous cell carcinoma. The expression of TP, MK and CD105 were all correlated with T-stage and lymph node metastasis. PMID: 18476626
- Thymidine phosphorylase did not increase the tumour invasion, but stimulated the migration and invasion of endothelial cells by two different mechanisms. PMID: 21386840
- transition state for the arsenolytic reaction PMID: 21222488
- altered function of hnRNP H1/H2 in tumor cells is a novel determinant of aberrant thymidine phosphorylase splicing thereby resulting in acquired chemoresistance to TP-activated fluoropyrimidine anticancer drugs. PMID: 21068389
- thymidine phosphorylase is expressed differently in gallbladder and bile duct cancer PMID: 20955617
- MNGIE is caused by mutations in the gene encoding thymidine phosphorylase, which lead to absolute or nearly complete loss of its catalytic activity, producing systemic accumulations of its substrates, thymidine and deoxyuridine. PMID: 20585803
- thymidine phosphorylase has a role in the induction of early growth response protein-1 and thrombospondin-1 by 5-fluorouracil in human cancer carcinoma cells PMID: 20372793
- Thymidine phosphorylase-derived sugars from overexpressing tumor cells accumulate in the cytoskeleton and to some extent in the cell membrane, enabling endothelial cells to migrate and invade towards tumor sites. PMID: 20488166
- TP may have a role in angiogenesis-dependent growth and migration of cholangiocarcinoma and in response to 5-fluorouracil chemotherapy PMID: 20355241
- Increased thymidine phosphorylase expression is associated with bladder cancers. PMID: 20112501
- dThdPase activity in gastric cancer cells was found to be correlated with venous invasion, supporting previous findings that it plays a role in tumor angiogenesis PMID: 9857235
- induction in tumoral stroma, but not in tumor cells, may promote angiogenesis in adenocarcinoma of the lung; may be important prognostic factor in adenocarcinoma of the lung PMID: 11920479
- inhibits the intracellular apoptotic signal transduction in the Fas-induced apoptotic pathway PMID: 11925935
- COX-2 is upregulated in endometrial cancer and facilitates tumor growth via angiogenesis produced in associated with VEGF and TP. PMID: 11957147
- thymidine phosphorylase is a major angiogenic factor in prostate carcinoma and its upregulation is likely to occur in the context of host immune response PMID: 11986782
- summary of research advances concerning thymidine phosphorylase in breast carcinoma (review) PMID: 12174926
- Biochemical defects of thymidine phosphorylase (hPD-ECGF) and a pathogenic G-to-A transition mutation at nucleotide 435 in the hPD-ECGF gene have been identified in two affected siblings with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). PMID: 12177387
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相關疾病：Mitochondrial DNA depletion syndrome 1, MNGIE type (MTDPS1)
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蛋白家族：Thymidine/pyrimidine-nucleoside phosphorylase family
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