TWF1 Antibody

中文名稱：

TWF1兔多克隆抗體
貨號：

CSB-PA622511LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA622511LA01HU at dilution of 1:100

Immunofluorescent analysis of Hela cells using CSB-PA622511LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TWF1 Polyclonal antibody
Uniprot No.：

Q12792
基因名：

TWF1
別名：

A6 antibody; A6 protein tyrosine kinase antibody; MGC105817 antibody; MGC23788 antibody; MGC41876 antibody; Protein A6 antibody; Protein tyrosine kinase 9 antibody; PTK9 antibody; PTK9 protein tyrosine kinase 9 antibody; TWF 1 antibody; twf1 antibody; TWF1_HUMAN antibody; Twinfilin 1 antibody; Twinfilin actin binding protein, homolog 1 antibody; Twinfilin antibody; Twinfilin, actin-binding protein, homolog 1 (Drosophila) antibody; Twinfilin, Drosophila, homolog of, 1 antibody; Twinfilin-1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Twinfilin-1 protein (199-252AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，TWF1 Antibody (CSB-PA622511LA01HU)，的標記方式是Non-conjugated。對于TWF1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA622511LB01HU	TWF1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA622511LC01HU	TWF1 Antibody, FITC conjugated
Biotin	CSB-PA622511LD01HU	TWF1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles.
基因功能參考文獻：
1. Univariate Cox regression analysis showed high expression of TWF1 to be independent prognostic indicator involved in overall survival and recurrence-free survival in lung adenocarcinoma, but not in lung squamous cell carcinoma PMID: 30391462
2. TWF1 and VIM are required for miR-30c to regulate breast cancer cell invasion. PMID: 23224145
3. An interleukin-6 family member, interleukin-11 is identified as a secondary target of twinfilin 1 in the microRNA-30c signalling pathway. PMID: 23340433
4. protein overexpression promotes cardiomyocyte hypertrophy PMID: 20571053
5. These data suggest that the association with an actin monomer induces a first-order conformational change within the twinfilin molecule. PMID: 12429826
6. mammals have two twinfilin isoforms, which are differentially expressed and regulated through distinct cellular signaling pathways PMID: 12807912
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相關疾病：

Defects in TWF1 has been found in a patient with isolated coloboma, a defect of the eye characterized by the absence of ocular structures due to abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Isolated colobomas may be associated with an abnormally small eye (microphthalmia) or small cornea.
亞細胞定位：

Cytoplasm. Cytoplasm, cytoskeleton.
蛋白家族：

Actin-binding proteins ADF family, Twinfilin subfamily
組織特異性：

Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver.
數據庫鏈接：

HGNC: 9620

OMIM: 610932

KEGG: hsa:5756

STRING: 9606.ENSP00000449428

UniGene: Hs.189075

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