TTI1 Antibody, HRP conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TTI1 Polyclonal antibody
Uniprot No.：

O43156
基因名：

TTI1
別名：

TTI1 antibody; KIAA0406 antibody; SMG10 antibody; TELO2-interacting protein 1 homolog antibody; Protein SMG10 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human TELO2-interacting protein 1 homolog protein (692-858AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.
基因功能參考文獻：
1. IP7, formed by IP6K2, binds CK2 to enhance its phosphorylation of the Tti1/Tel2 complex, thereby stabilizing DNA-PKcs and ATM. This process stimulates p53 phosphorylation at serine 15 to activate the cell death program. PMID: 24657168
2. TTI1 and TTI2 protect cells from spontaneous DNA damage, and are required for the establishment of the intra-S and G2/M checkpoin PMID: 20810650
3. Data show that that knockdown of either Tti1 or Tel2 causes disassembly of mTORC1 and mTORC2. PMID: 20427287
亞細胞定位：

Cytoplasm.
蛋白家族：

Tti1 family
組織特異性：

Widely expressed.
數據庫鏈接：

HGNC: 29029

OMIM: 614425

KEGG: hsa:9675

STRING: 9606.ENSP00000362546

UniGene: Hs.655481

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