TSSC1 Antibody

說明書

產品詳情

Uniprot No.：

Q53HC9
基因名：

EIPR1
別名：

EIPR1 antibody; TSSC1EARP and GARP complex-interacting protein 1 antibody; Endosome-associated recycling protein-interacting protein antibody; Golgi-associated retrograde protein-interacting protein antibody; Tumor-suppressing STF cDNA 1 protein antibody; Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat,Monkey
免疫原：

Synthesized peptide derived from the C-terminal region of Human TSSC1.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:10000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein(PubMed:27440922). Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex. Controls proper insulin distribution and secretion, and retention of cargo in mature dense core vesicles. Required for the stability of the endosome-associated retrograde protein (EARP) complex subunits and for proper localization and association of EARP with membranes.
基因功能參考文獻：
1. Fluorescence recovery after photobleaching shows that TSSC1 is required for efficient recruitment of GARP to the TGN. These studies thus demonstrate that TSSC1 plays a critical role in endosomal retrieval pathways as a regulator of both GARP and EARP function. PMID: 27440922
2. TSSC1 inhibits breast cancer cell invasion. Subsequently, TSSC1 is confirmed as a target of Runx2 and is negatively regulated by Runx2. PMID: 23933319
亞細胞定位：

Golgi apparatus, trans-Golgi network.
蛋白家族：

WD repeat EIPR1 family
數據庫鏈接：

HGNC: 12383

OMIM: 608998

KEGG: hsa:7260

STRING: 9606.ENSP00000371559

UniGene: Hs.502770

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