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中文名稱：
TRIM35兔多克隆抗體
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貨號(hào)：
CSB-PA235427
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規(guī)格：
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圖片：
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Gel: 8%SDS-PAGE,Lysate: 40 μg,Lane 1-4: 293T cells, HepG2 cells, K562 cells, Hela cells,Primary antibody: CSB-PA235427(TRIM35 Antibody) at dilution 1/800 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 15 seconds
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：
TRIM35
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別名：
0710005M05Rik antibody; A430106H13Rik antibody; AW046487 antibody; Hemopoietic lineage switch protein 5 antibody; HLS5 antibody; KIAA1098 antibody; Macrophage derived apoptosis inducing RBCC protein antibody; MAIR antibody; MGC17233 antibody; mKIAA1098 antibody; NC8 antibody; Protein MAIR antibody; Protein Nc8 antibody; TRI35_HUMAN antibody; TRIM35 antibody; Tripartite motif containing 35 antibody; Tripartite motif containing protein 35 antibody; Tripartite motif-containing protein 35 antibody
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宿主：
Rabbit
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反應(yīng)種屬：
Human
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免疫原：
Fusion protein of Human TRIM35
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免疫原種屬：
Homo sapiens (Human)
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標(biāo)記方式：
Non-conjugated
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抗體亞型：
IgG
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純化方式：
Antigen affinity purification
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濃度：
It differs from different batches. Please contact us to confirm it.
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保存緩沖液：
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產(chǎn)品提供形式：
Liquid
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應(yīng)用范圍：
ELISA,WB
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推薦稀釋比：
| Application |
Recommended Dilution |
| ELISA |
1:2000-1:5000 |
| WB |
1:500-1:2000 |
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Protocols：
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儲(chǔ)存條件：
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
靶點(diǎn)詳情
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功能：
E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response. Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via DDX58/RIG-I signaling pathway. Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2. Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling. Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway. Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth.
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基因功能參考文獻(xiàn)：
- Authors subsequently investigated whether miR-4417 and TRIM35 regulate HCC cell proliferation and apoptosis through PKM2 Y105 phosphorylation, and the results supported our speculation that miR-4417 targets TRIM35 and regulates the Y105 phosphorylation of PKM2 to promote hepatocarcinogenesis. PMID: 28394882
- Data suggest that pyruvate kinase isoform M2 (PKM2)/tripartite motif-containing 35 (TRIM35) expression could be a biomarker for the prognosis of hepatocellular carcinoma (HCC) and target for cancer therapy. PMID: 25576919
- TRIM35 regulates the Warburg effect and tumorigenicity through interaction with PKM2 in hepatocellular carcinoma. PMID: 25263439
- gene located on chromosome 8p21, a region implicated in leukemias and solid tumors; enforced expression inhibited cell growth, clonogenicity, and tumorigenicity; conceivable HLS5 is one of the tumor suppressor genes thought to reside at the 8p21 locus PMID: 14662771
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亞細(xì)胞定位：
Cytoplasm. Nucleus.
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蛋白家族：
TRIM/RBCC family
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數(shù)據(jù)庫鏈接：
Most popular with customers
Gel: 8%SDS-PAGE,Lysate: 40 μg,Lane 1-4: 293T cells, HepG2 cells, K562 cells, Hela cells,Primary antibody: CSB-PA235427(TRIM35 Antibody) at dilution 1/800 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 15 seconds
