TRIAP1 Antibody
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中文名稱：TRIAP1兔多克隆抗體
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貨號：CSB-PA024443ESR2HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA024443ESR2HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA024443ESR2HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) TRIAP1 Polyclonal antibody
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Uniprot No.：
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基因名：TRIAP1
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別名：p53-inducible cell-survival factor antibody; p53CSV antibody; Protein 15E1.1 antibody; TP53-regulated inhibitor of apoptosis 1 antibody; TRIA1_HUMAN antibody; Triap1 antibody; WF 1 antibody; WF1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human TP53-regulated inhibitor of apoptosis 1 protein (1-76AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis.
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基因功能參考文獻：
- TRIAP1 is regulated by miR-320b and has a role in progression in nasopharyngeal carcinoma PMID: 27428374
- Results describe the upregulation of TRIAP1 in drugresistant breast cancer cells. Its experimental modulation changed breast tumor cells sensitivity to doxorubicin, thus confirming its role in drug resistance. PMID: 25998939
- TRIAP1 is Conserved Specific Coregulators of the p21:PUMA Expression Ratio. PMID: 23684607
- Under specific conditions of stress, p53 regulates transcription of p53CSV and that p53CSV is one of the important players in the p53-mediated cell survival. PMID: 15735003
- Upregulated in at least 50% of multiple myeloma cases tested. PMID: 19171422
- HSPC132 is p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway PMID: 15735003
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亞細胞定位：Mitochondrion. Mitochondrion intermembrane space.
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蛋白家族：TRIAP1/MDM35 family
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數據庫鏈接：
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