TRDN Antibody, Biotin conjugated
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中文名稱：TRDN兔多克隆抗體, Biotin偶聯(lián)
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貨號：CSB-PA024398LD01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) TRDN Polyclonal antibody
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Uniprot No.：
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基因名：TRDN
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別名：dJ166D18.1 antibody; DKFZp779I2253 antibody; MGC88285 antibody; OTTHUMP00000040354 antibody; TDN antibody; TRDN antibody; TRDN_HUMAN antibody; Triadin antibody; TRISK 51 antibody; TRISK antibody; TRISK51 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Triadin protein (75-161AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
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基因功能參考文獻：
- The lncRNA TRDN-AS regulates the balance between cardiac and skeletal isoforms of triadin. PMID: 29126880
- CLIMP-63 (also known as CKAP4), is the partner of triadin, is responsible for this association of triads and microtubules. PMID: 27562070
- A compound heterozygous mutation in the triadin gene resulted in a particularly arrhythmogenic phenotype with with cardiac arrest in two siblings. PMID: 26768964
- We describe a new family with cathecholaminergic polymorphic ventricular tachycardia (CPVT) linked to the Triadin gene. PMID: 26200674
- Common variants in TRDN and CALM1 are associated with increased risk of sudden cardiac death in patients with chronic heart failure. PMID: 26196381
- TRDN is a novel underlying genetic basis for recessively inherited Long-QT syndrome. PMID: 25922419
- Data show that triadin (TRDN) is a new gene responsible for an autosomal recessive form of ctecholaminergic polymorphic ventricular tachycardia (CPVT). PMID: 22422768
- The researchers found evidence that TRDN may be a susceptibility or marker gene for IgA nephropathy PMID: 19890582
- gene organization and cloning of the major isoform PMID: 12659871
- Histidine-rich Ca-binding protein may play a key role in the regulation of SR Ca cycling through its direct interactions with SERCA2 and triadin, mediating a fine cross talk between SR Ca uptake and release in the heart. PMID: 17526652
- proteasome inhibition led to an accumulation of two new modified forms of triadin-1 that were seen with triadin-1 only when it is not glycosylated on Asn(75). PMID: 18025088
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相關(guān)疾病：Ventricular tachycardia, catecholaminergic polymorphic, 5, with or without muscle weakness (CPVT5)
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亞細胞定位：Cell membrane. Sarcoplasmic reticulum membrane; Single-pass type II membrane protein.
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數(shù)據(jù)庫鏈接：
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