TOM1 Antibody

說明書

中文名稱：

TOM1兔多克隆抗體
貨號：

CSB-PA024043GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

O60784
基因名：

TOM1
別名：

TOM1 antibody; Target of Myb protein 1 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human TOM1
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May be involved in intracellular trafficking. Probable association with membranes.
基因功能參考文獻：
1. This study demonstrated that Tom1 is localized in dystrophic neurites of brain in patient with Alzheimer's disease. PMID: 27206884
2. Tom1 modulates binding of Tollip to phosphatidylinositol 3-phosphate via a coupled folding and binding mechanism. PMID: 26320582
3. candidate multiple myeloma risk locus PMID: 26007630
4. phosphatidylinositol 5-monophosphate (PI5P) enrichment in signaling endosomes prevents endosomal maturation through the recruitment of TOM1, and point to a new function of PI5P in regulating discrete maturation steps in the endosomal system. PMID: 25588840
5. It was shown that that myosin VI, in concert with Tom1, plays a crucial role in autophagy. Tom1 was identified as a myosin VI binding partner on endosomes. PMID: 23023224
6. TOM1 is a microRNA-126 target that may have an important role in regulating innate immune responses in the cystic fibrosis lung. PMID: 20083669
7. a Tom1-Tollip complex functions as a factor that links polyubiquitinated proteins to clathrin PMID: 14563850
8. marked recruitment of TOM1 to endosomes was observed in cells overexpressing endofin or its carboxyl-terminal fragment PMID: 14613930
9. Tollip and Tom1 form a complex and regulate endosomal trafficking of ubiquitinated proteins PMID: 15047686
10. The results suggest that TOM1 is an important molecule for membrane recruitment of clathrin, and that endofin is able to exploit this recruitment at the endosome. PMID: 15657082
11. A 3-marker haplotype of SNPs within TOM1 was associated with psychotic bipolar affective disorder linkage PMID: 17671966
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亞細胞定位：

Cytoplasm. Membrane; Peripheral membrane protein.
蛋白家族：

TOM1 family
組織特異性：

Widely expressed. Highly expressed in skeletal muscle, heart, placenta and liver.
數據庫鏈接：

HGNC: 11982

OMIM: 604700

KEGG: hsa:10043

STRING: 9606.ENSP00000413697

UniGene: Hs.474705

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