TNRC6B Antibody, Biotin conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TNRC6B Polyclonal antibody
Uniprot No.：

Q9UPQ9
基因名：

TNRC6B
別名：

TNRC6B antibody; KIAA1093 antibody; Trinucleotide repeat-containing gene 6B protein antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Trinucleotide repeat-containing gene 6B protein (639-779AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.
基因功能參考文獻：
1. The rs12484776 significantly contributes to uterine myoma risk among Saudi women, both in single and also in synergistic cooperation with rs2280543, rs7913069, and rs1056836 markers. PMID: 27987337
2. single nucleotide polymorphisms in the TNRC6B gene is associated with uterine fibroid. PMID: 23604678
3. Trinucleotide repeat containing 6B (TNRC6B) rs12484776 associated with uterine fibroid volume in european americans. PMID: 23892540
4. Our findings indicate that TNRC6B, is recruited to miRNA targets through an interaction between their N-terminal domain and an Argonaute protein PMID: 19383768
亞細胞定位：

Cytoplasm, P-body.
蛋白家族：

GW182 family
數據庫鏈接：

HGNC: 29190

OMIM: 610740

KEGG: hsa:23112

STRING: 9606.ENSP00000401946

UniGene: Hs.372082

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