TMOD1 Antibody, HRP conjugated

說明書

中文名稱：

TMOD1兔多克隆抗體, HRP偶聯
貨號：

CSB-PA023909LB01HU
規格：

￥880
其他：

產品詳情
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相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TMOD1 Polyclonal antibody
Uniprot No.：

P28289
基因名：

TMOD1
別名：

Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod), TMOD1, D9S57E TMOD
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Tropomodulin-1 protein (105-359aa)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus.
基因功能參考文獻：
1. Tmod1 function in mouse and human erythroblasts, was investigated. PMID: 28729432
2. The mutation reduced binding affinity for both Lmod2 and Tmod1. The effect of the K15N mutation on Tpm1.1 binding to Lmod2 and Tmod1 provides a molecular rationale for the development of familial dilated cardiomyopathies . PMID: 26873245
3. Study highlighted a novel TMOD1-mediated link between NF-kappaB activation and MMP13 induction, which accounts in part for the NF-kappaB-dependent malignant phenotype of TNBC. PMID: 25398440
4. Tmod1 and Tmod3 showed somewhat different tropomyosin-binding site utilization. PMID: 24922351
5. The structures and biochemical analysis of structure-inspired mutants showed that one Tmod molecule interacts with three actin subunits at the pointed end, while also contacting two tropomyosin molecules on each side of the filament. PMID: 25061212
6. Tropomyosin requires an intact N-terminal coiled coil to interact with this protein PMID: 11964245
7. levels of TM1, TM2 and TM3 are reduced in human transitional cell carcinoma cells, but significantly upregulated by inhibition of the mitogen-activated protein kinase-signaling pathway PMID: 15095301
8. The N-terminal "KRK ring" may participate in balancing electrostatic force with hydrophobic interaction in dimerization of TM and its binding to E-Tmod. PMID: 16297372
9. study identifies several amino acid residues on Tmod-1 that are important for its interaction with TM5 (a nonmuscle TM isoform) PMID: 16434395
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亞細胞定位：

Cytoplasm, cytoskeleton.
蛋白家族：

Tropomodulin family
組織特異性：

Highly expressed in the erythrocyte, heart and skeletal muscle.
數據庫鏈接：

HGNC: 11871

OMIM: 190930

KEGG: hsa:7111

STRING: 9606.ENSP00000259365

UniGene: Hs.404289

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