TKFC Antibody

中文名稱：

TKFC兔多克隆抗體
貨號：

CSB-PA659468LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA659468LA01HU diluted at 1:400 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of HepG2 cells with CSB-PA659468LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TKFC Polyclonal antibody
Uniprot No.：

Q3LXA3
基因名：

TKFC
別名：

ATP dependent dihydroxyacetone kinase antibody; Bifunctional ATP dependent dihydroxyacetone kinase/FAD AMP lyase (cyclizing) antibody; DAK antibody; DHA kinase antibody; Dha kinase/FMN cyclase antibody; DHAK_HUMAN antibody; Dihydroxyacetone kinase antibody; Dihydroxyacetone kinase 2 antibody; Dihydroxyacetone kinase 2 homolog (S. cerevisiae) antibody; Dihydroxyacetone kinase 2 homolog (yeast) antibody; FAD AMP lyase (cyclic FMN forming) antibody; FAD AMP lyase (cyclizing) antibody; FAD-AMP lyase (cyclic FMN forming) antibody; FAD-AMP lyase (cyclizing) antibody; FMN cyclase antibody; Glycerone kinase antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Triokinase/FMN cyclase protein (396-561AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，TKFC Antibody (CSB-PA659468LA01HU)，的標記方式是Non-conjugated。對于TKFC Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA659468LB01HU	TKFC Antibody, HRP conjugated	ELISA
FITC	CSB-PA659468LC01HU	TKFC Antibody, FITC conjugated
Biotin	CSB-PA659468LD01HU	TKFC Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response.
基因功能參考文獻：
1. The peptide fragment (m/z 520.3) of DAK is a promising biomarker to guide timing of antiviral treatment and to avoid liver biopsy in compensated chronic hepatitis B patients. PMID: 24289155
2. analysis of human triokinase/FMN cyclase reveals that kinase activity requires intact homodimers, but cyclase requires only a truncated, single domain subunit PMID: 24569995
3. Evidence supports that a single protein sustains both FMN cyclase and ATP-dependent Dha kinase activities, probably in a single active center PMID: 16289032
4. DAK, the physiological suppressor of cytoplasmic viral RNA sensor MDA5, specifically inhibits MDA5- but not RNA helicase RIG-I-mediated innate antiviral signaling. PMID: 17600090
蛋白家族：

Dihydroxyacetone kinase (DAK) family
組織特異性：

Detected in erythrocytes (at protein level).
數據庫鏈接：

HGNC: 24552

OMIM: 615844

KEGG: hsa:26007

STRING: 9606.ENSP00000378360

UniGene: Hs.6278

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