TINF2 Antibody
-
中文名稱：TINF2兔多克隆抗體
-
貨號：CSB-PA008737
-
規格：￥1090
-
其他：
產品詳情
-
Uniprot No.：
-
基因名：TINF2
-
別名：AW552114 antibody; D14Wsu146e antibody; DKCA3 antibody; MGC94711 antibody; TERF 1 (TRF 1) interacting nuclear factor 2 antibody; TERF 1 interacting nuclear factor 2 antibody; TERF1 (TRF1) interacting nuclear factor 2 antibody; TERF1 interacting nuclear factor 2 antibody; TERF1-interacting nuclear factor 2 antibody; Tin 2 antibody; TIN2 antibody; TINF 2 antibody; Tinf2 antibody; TINF2_HUMAN antibody; TRF 1 interacting nuclear factor 2 antibody; TRF1 interacting nuclear factor 2 antibody; TRF1-interacting nuclear protein 2 antibody
-
宿主：Rabbit
-
反應種屬：Human
-
免疫原：Synthesized peptide derived from the Internal region of Human TIN2.
-
免疫原種屬：Homo sapiens (Human)
-
標記方式：Non-conjugated
-
抗體亞型：IgG
-
純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-
濃度：It differs from different batches. Please contact us to confirm it.
-
保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
-
產品提供形式：Liquid
-
應用范圍：WB, IHC, ELISA
-
推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:10000 -
Protocols：
-
儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
-
用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
-
功能：Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix.
-
基因功能參考文獻：
- The TIN2 plays an important role in maintaining the stable shelterin complex required for proper telomere end protection. PMID: 29160297
- We report ophthalmic findings in twins with Revesz syndrome due to a previously unreported mutation in TINF2 and propose that phenotypic and molecular overlaps between DKC spectrum disorders and pediatric retinal vasculopathies may reflect a shared pathophysiologic basis. PMID: 28095086
- demonstrate here the presence of a novel spliced isoform of TIN2 in chronic lymphocytic leukemia (CLL), related to deletion of exon 2 in the TIN2 gene PMID: 28575699
- data supports a mechanism whereby telomerase deficiency and subsequent shortened telomeres initiate a DNA damage response and create a pro-oxidant environment, especially in Dyskeratosis Congenita cells carrying TINF2 mutations PMID: 26859482
- telomerase elongates telomeres at a reduced frequency in TIN2-R282H heterozygous cells; this recruitment defect is further corroborated by examining the effect of this mutation on telomerase-telomere co-localization. PMID: 26230315
- Our findings identify TINF2 as a mutant telomere gene in familial pulmonary fibrosis and suggest that infertility may precede the presentation of pulmonary fibrosis in a small subset of adults with telomere syndromes PMID: 25539146
- A potential mitotic regulation of TIN2 by phosphorylation, is reported. PMID: 23977114
- results suggest a link between telomeric proteins (TIN2)and metabolic control, providing an additional mechanism by which telomeric proteins regulate cancer and aging PMID: 22885005
- Results suggests that the disruption of TIN2-TRF1 interaction may contribute to the severe dyskeratosis congenita phenotype observed in the context of the TIN2 truncation mutation. PMID: 21477109
- The positive correlation between telomere length in dyskeratosis congenital and percent of LINE-1 methylation was restricted to TINF2 mutations. PMID: 21981348
- Frameshift or nonsense mutations in TIN2 gene having very short telomeres are found in patients with dyskeratosis congenita. PMID: 21199492
- Siah2 acts as an E3 ligase to directly ubiquitylate TIN2 in vitro. PMID: 22064479
- These results demonstrate the important roles that Sp1 and NF-kappaB play in regulating the expression of the human telomere-binding protein TIN2. PMID: 21731707
- The presence of dysfunctional telomeres in chronic lymphocytic leukemia did not correlate with telomere shortening or chromatin marks deregulation but with a down-regulation of 2 shelterin genes: ACD and TINF2. PMID: 21355086
- TIN2 mutations in DC may compromise the telomere recruitment of telomerase, leading to telomere shortening and the associated pathogenesis. PMID: 21536674
- exon 6 of TINF2 natural mutations in 2/142 Japanese patients with acquired acquired bone marrow failure syndromes PMID: 20560964
- TINF2 mutation of shelterin complex is associated with dyskeratosis congenita. PMID: 20979174
- The expression of TINF2 may work to reduce the telomere length in precancerous lesions and offer new insight into the mechanism of carcinogenesis in gastric cancer. PMID: 20127252
- TIN2-anchored TPP1 plays a major role in the recruitment of telomerase to telomeres in human cells. PMID: 20404094
- Co-localises with the interstitial TTAGGG repeats in interstitial telomeres. PMID: 11938440
- Down-regulation of TRF1, TRF2 and TIN2 genes is important to maintain telomeric DNA for gastric cancers. PMID: 12530079
- TIN2 alters the conformation of TRF1, which favours a tertiary telomeric structure that hinders telomerase from gaining access to telomeres PMID: 12835755
- Partial knockdown of TIN2 by small hairpin RNA in a telomerase-positive cell line resulted in telomere elongation, which is typical of reduced TRF1 function. PMID: 15133513
- TIN2 mutants defective in binding of TRF1 or TRF2 induce a DNA damage response and destabilize TRF1 and TRF2 at telomeres in human cells. PMID: 15292264
- TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres PMID: 15316005
- May be involved in multistep hepatocarcinogenesis by playing crucial role in telomere shortening. PMID: 15632001
- a novel extra-telomeric organization of TIN2 is associated with the control of cell proliferation; TIN2 is an important regulator of mammary epithelial differentiation PMID: 15741234
- coordinated interactions among TPP1, TIN2, TRF1, and TRF2 may ensure robust assembly of the telosome, telomere targeting of its subunits, and, ultimately, regulated telomere maintenance PMID: 16880378
- TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita. PMID: 18252230
- Results suggest that distinct TIN2 complexes exist and that TIN2-15C-sensitive subcomplexes are particularly important for cell survival in the absence of functional p53. PMID: 18443218
- In a large series, TINF2 mutations account for approximately 11% of all patients with dyskeratosis congenita. PMID: 18669893
- conclude that a significant proportion of patients who underwent unrelated donor hematopoietic stem cell transplantation for severe aplastic anemia harbored mutations in TINF2 and may have had occult dyskeratosis congenita PMID: 19090550
- Our results suggest a dual role for TIN2 in mediating the function of the shelterin complex and tethering telomeres to the nuclear matrix. PMID: 19229133
顯示更多
收起更多
-
相關疾病：Dyskeratosis congenita, autosomal dominant, 3 (DKCA3); Dyskeratosis congenita, autosomal dominant, 5 (DKCA5)
-
亞細胞定位：Nucleus. Chromosome, telomere. Note=Associated with telomeres.; [Isoform 1]: Nucleus matrix.
-
組織特異性：Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
-
數據庫鏈接：
Most popular with customers
-
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC, IF, FC
Species Reactivity: Human, Mouse, Rat
-
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human
-
-
-
-
-
