TIAL1 Antibody, HRP conjugated

說明書

中文名稱：

TIAL1兔多克隆抗體, HRP偶聯
貨號：

CSB-PA023529HB01HU
規格：

￥880
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TIAL1 Polyclonal antibody
Uniprot No.：

Q01085
基因名：

TIAL1
別名：

Aging associated gene 7 protein antibody; Nucleolysin TIAR antibody; T cluster binding protein antibody; TCBP antibody; TIA 1 related nucleolysin antibody; TIA-1-related protein antibody; TIA1 cytotoxic granule associated RNA binding protein like 1 antibody; TIA1 related protein antibody; TIAL1 antibody; TIAR antibody; TIAR_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Nucleolysin TIAR protein (9-277AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.
基因功能參考文獻：
1. we identified MT1JP as a critical factor in restraining cell transformation by modulating p53 translation through interactions with TIAR PMID: 26909858
2. TIAL1 inhibition of the exon 8 exclusion led to a decrease in SIRT1-Exon8 mRNA levels. PMID: 24566137
3. A role for TIAR is identified in T-cells for control of translational specificity. PMID: 24927121
4. findings demonstrate that TIAR recognition motif 2 (RRM2), together with its C-terminal extension, is the major contributor for the high-affinity (nM) interactions of TIAR with target RNA sequences PMID: 23603827
5. results report the identification of TIAR as a novel player in the regulation of calcitonin/CGRP alternative RNA processing PMID: 12917321
6. HuR, KSRP and TIAR are bound to one or more loci in the 3'UTR of IL-8 in breast cancer cells. PMID: 15514971
7. TIAR seems to be involved in the post-transcriptional regulation of human iNOS expression PMID: 16191398
8. Furthermore, we found that overexpression of DISC1 in SH-SY5Y cells induces the assembly of eIF3- and TIA-1-positive stress granules (SGs), discrete cytoplasmic granules formed in response to environmental stresses. PMID: 16243297
9. TIAR-mediated inhibition of translation factor expression elicits a sustained repression of protein biosynthesis in cells responding to stress. PMID: 16537914
10. TIAL1 maintains cytochrome c biosynthesis. PMID: 16581801
11. adenosine/uridine (AU)-rich element-binding proteins TIA-1 (T-cell intracellular antigen-1), TIAR (TIA-1-related protein), and HuR (Hu antigen R) interact with the beta-F1-ATPase mRNA through an AU-rich sequence located to the 3'-UTR. PMID: 16890199
12. Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation. PMID: 17486099
13. Our in vivo data, taken together with previous in vitro results, show that K-SAM splicing activation involves cooperative binding of TIA-1 and U1 snRNP to the exon's 5' splice site region. PMID: 17512901
14. Results report the identification of a C-rich signature motif present in TIAR target mRNAs whose association with TIAR decreases following exposure to a stress-causing agent. PMID: 17682065
15. Show increased TIA-1 positive cytotoxic T-lymphocytes in inflamed mucosa of patients with inflammatory bowel disease. PMID: 17869012
16. In contrast with previous assumptions, the mutated residues are buried within the hydrophobic interior of the domain, where they would be likely to destabilize the RRM fold rather than directly inhibit RNA binding. PMID: 18201561
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亞細胞定位：

Cytoplasm. Nucleus. Cytolytic granule. Cytoplasm, Stress granule.
數據庫鏈接：

HGNC: 11804

OMIM: 603413

KEGG: hsa:7073

STRING: 9606.ENSP00000358089

UniGene: Hs.501203

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