THAP11 Antibody

中文名稱：

THAP11兔多克隆抗體
貨號：

CSB-PA846612LA01HU
規(guī)格：

￥440
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) THAP11 Polyclonal antibody
Uniprot No.：

Q96EK4
基因名：

THAP11
別名：

CTG B43a antibody; CTG B45d antibody; HRIHFB2206 antibody; RONIN antibody; THA11_HUMAN antibody; THAP 11 antibody; THAP domain containing 11 antibody; THAP domain-containing protein 11 antibody; Thap11 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human THAP domain-containing protein 11 protein (1-313AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，THAP11 Antibody (CSB-PA846612LA01HU)，的標(biāo)記方式是Non-conjugated。對于THAP11 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA846612LB01HU	THAP11 Antibody, HRP conjugated	ELISA
FITC	CSB-PA846612LC01HU	THAP11 Antibody, FITC conjugated
Biotin	CSB-PA846612LD01HU	THAP11 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

功能：

Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers.
基因功能參考文獻(xiàn)：
1. A transcriptional repressor network including THAP domain containing 11 protein (THAP11) was identified and negatively regulates endogenous PARKIN abundance. PMID: 29269392
2. We sequenced THAP11 by Sanger sequencing and discovered a potentially pathogenic, homozygous variant in THAP11, c.240C > G (p.Phe80Leu). Further, we provide functional data in model organisms that suggests that both HCFC1 and THAP11 are essential for normal brain development and neural precursor differentiation. PMID: 28449119
3. the crystal structure of the C-ter region of THAP11 forms a left-handed parallel homo-dimeric coiled-coil structure possessing several unusual features. PMID: 26975212
4. The M4 motif (ACTAYRNNNCCCR) is a functional regulatory bipartite cis-element, which engages a THAP11/HCF-1 complex via binding to the ACTAYR module, while the CCCRRNRNRC subsequence part constitutes a binding platform for Ikaros and NFKB1 PMID: 27576892
5. THAP11, ZNF143, and HCF-1 form a mutually dependent complex on chromatin, which is independent of E2F occupancy. PMID: 25437553
6. that THAP11 reversibly regulated erythroid and megakaryocytic differentiation. PMID: 24637716
7. HCFC1 is a common component of active human CpG-island promoters and coincides with ZNF143, THAP11, YY1, and GABP transcription factor occupancy. PMID: 23539139
8. In HCC patients, the expression of THAP11 mRNA significantly correlated with PCBP1 mRNA expression. Our results suggest a novel role of THAP11 in CD44 alternative splicing and hepatoma invasion PMID: 22673507
9. identify THAP11 as a transcriptional regulator differentially expressed in human colon cancer PMID: 22371484
10. the induced THAP11 might be one of transcriptional regulators of c-Myc expression in CML cell. PMID: 21400515
11. Results suggest that THAP11 functions as a cell growth suppressor by negatively regulating the expression of c-Myc. PMID: 19008924
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亞細(xì)胞定位：

Nucleus. Cytoplasm.
蛋白家族：

THAP11 family
數(shù)據(jù)庫鏈接：

HGNC: 23194

OMIM: 609119

KEGG: hsa:57215

STRING: 9606.ENSP00000304689

UniGene: Hs.632200

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