TFAP2C Antibody
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中文名稱：TFAP2C兔多克隆抗體
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貨號：CSB-PA000894
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規格：￥1090
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圖片：
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Western Blot analysis of HuvEc cells using AP-2γ Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：TFAP2C
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別名：Activating enhancer binding protein 2 gamma antibody; Activating enhancer-binding protein 2 gamma antibody; AP2-gamma antibody; AP2C_HUMAN antibody; AP2g antibody; AP2gamma antibody; ERF 1 antibody; ERF1 antibody; Estrogen receptor factor 1 antibody; hAP 2g antibody; hAP2g antibody; TFAP 2C antibody; TFAP 2G antibody; Tfap2c antibody; TFAP2G antibody; Transcription factor AP 2 gamma (activating enhancer binding protein 2 gamma) antibody; Transcription factor AP 2 gamma antibody; Transcription factor AP-2 gamma antibody; Transcription factor ERF 1 antibody; Transcription factor ERF-1 antibody; Transcription factor ERF1 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from the C-terminal region of Human AP-2γ.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:40000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
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基因功能參考文獻：
- Study discovered a novel enhancer HER2 gene body enhancer (HGE) in the 3' gene body of HER2. The HGE activates promoters 1 and 2 in trans., and hence the TFAP2C-mediated transcriptional induction of HER2 expression in breast cancer samples. PMID: 29035388
- This study shows that TFAP2C promoted lung tumor progression by upregulation of TGFBR1 and consequent activation of PAK1 signaling. PMID: 27885255
- miR-137 is a Slug-induced miRNA that relays the pro-metastatic effects of Slug by targeting TFAP2C in non-small cell lung cancer cells. PMID: 28610956
- TFAP2C might increase oncogenic miR-183 expression and consequently downregulate tumor-suppressive AKAP12 and decrease tumor-suppressive miR-33a expression and subsequently induce CDK6 in NSCLC cells. PMID: 27593936
- Higher TFAP2C protein expression correlates with poor overall survival after 10 years of diagnosis in ERalpha-positive breast cancer. PMID: 26160249
- In all three groups[preeclamptic placentas , healthy control and smokers] expression rates of AP-2gamma did not differ between primary, secondary and tertiary villi. PMID: 25315380
- TFAP2C has an important role in regulated luminal-specific genes and may be a viable therapeutic target in breast cancer. PMID: 24469049
- ShRNA knockdown of AP-2gamma in neuroblastoma cells results in significant inhibit of cell proliferation. PMID: 24969902
- Knockdown of TFAP2C or RET inhibited activation of ERK and AKT in MCF-7 cells. Knockdown of TFAP2C, which controls ER (estrogen receptor) and RET, had a greater effect on cell growth than either RET or ER alone. PMID: 24045439
- role for TFAP2C in melanoma via its regulation of ECM1 PMID: 24023917
- TFAP2C amplification and overexpression represents a genetic dependency in ERBB2+ve breast cancer. PMID: 23334330
- TFAP2C regulates expression of the RET proto-oncogene through five AP-2 regulatory sites in the RET promoter. PMID: 22878616
- Results demonstrate that TFAP2C regulates the expression of GPX1, which influences the redox state and sensitivity to oxidative stress induced by peroxides. PMID: 22964634
- results substantiate a role for Tcfap2c/ TFAP2C in supporting proliferation and repressing differentiation in cellular compartments representing immature/ progenitor cells.[review] PMID: 22560121
- We demonstrated that TFAP-2gamma is one of the transcription factors involved in the HuPAR-2 expression in human villous trophoblast cells. PMID: 22702469
- demonstrated that while TFAP2C and Myc can downregulate the CDKN1A promoter independently, KDM5B acts as a corepressor dependent on the other two proteins PMID: 22371483
- AP-2gamma is a novel collaborative factor in ERalpha-mediated transcription. PMID: 21572391
- miR-214 is highly expressed in human melanomas and the data suggest a critical role for this miRNA in disease progression and the establishment of distant metastases through suppression of TFAP2C. PMID: 21468029
- Overexpression of TFAP2C is associated with hormone responsive breast carcinoma. PMID: 20629094
- AP-2 gamma and Dlx 3, together with an additional transcription factor(s) that are conserved between humans and mice, are required for trophoblast-specific expression of 3 beta-HSD VI. PMID: 11773066
- AP-2gamma is important in regulation of ErbB-3 expression in human mammary epithelial and lung fibroblast cells PMID: 11859873
- we have identified a potential trophoblast cell-specific regulatory element located 6 kb upstream of the murine AP-2gamma gene transcription start site, and that Sp1 and Sp3 bind to cis-regulatory elements located in the promoter proximal region PMID: 12801994
- AP-2gamma expression in breast cancer cells is induced by oestrogens through binding of the oestrogen receptor to a response element within the 5'-untranslated region. PMID: 14565844
- Abundant expression of AP-2gamma is associated with intratubular germ cell neoplasias PMID: 15700319
- Expression microarray results in human breast carcinoma cells with forced p53 expression revealed AP-2gamma as a putative transcriptional target of p53. PMID: 16636674
- TFAP2C is the key regulator of hormone responsiveness in breast carcinoma cells through the control of multiple pathways of estrogen signaling. TFAP2C regulates the expression of ERalpha directly by binding to the ERalpha promoter. PMID: 17875680
- Wwox and Ap2gamma emerge are tumor biomarkers that may be superior to PR and Her2 in predicting tamoxifen response PMID: 17947476
- AP2 transcription factors may play decisive pacemaker roles in initiating and coordinating budding and branching processes during formation of the fetal breast anlage PMID: 18042070
- Down-modulation of AP-2gamma expression in tumor cells by RNA interference led to enhanced tumor growth and reduced chemotherapy-induced cell death, as well as migration and invasion. PMID: 18443366
- Reduced expression levels of nuclear AP2gamma is associated with the pathogenesis of basal-like differentiation in breast cancer. PMID: 19130459
- Data show that the combination of increasing chromatin accessibility and inducing TFAP2C provides a more robust activation of the ERalpha gene in ERalpha-negative breast cancer cells. PMID: 19458056
- ErbB2, CDH2, HPSE and IGSF11 are identified as AP-2gamma target genes in breast cancer cells. PMID: 19671168
- AP-2gamma promotes proliferation in breast tumour cells by direct repression of the CDKN1A gene. PMID: 19798054
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亞細胞定位：Nucleus.
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蛋白家族：AP-2 family
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數據庫鏈接：
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