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TDRD3 Antibody, HRP conjugated

說明書

中文名稱：

TDRD3兔多克隆抗體, HRP偶聯
貨號：

CSB-PA863996LB01HU
規格：

￥880
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TDRD3 Polyclonal antibody
Uniprot No.：

Q9H7E2
基因名：

TDRD3
別名：

4732418C03Rik antibody; 6720468N18 antibody; FLJ21007 antibody; OTTHUMP00000018485 antibody; TDRD 3 antibody; tdrd3 antibody; TDRD3_HUMAN antibody; Tudor domain containing 3 antibody; Tudor domain containing protein 3 antibody; Tudor domain-containing protein 3 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Tudor domain-containing protein 3 protein (401-651AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.
基因功能參考文獻：
1. Structural basis of the interaction between TOP3B and the TDRD3 auxiliary factor has been reported. PMID: 28176834
2. Top3b proteins from several animals associate with polyribosomes, which are units of mRNA translation, whereas the Top3 homologs from E. coli and yeast lack the association. The Top3b-polyribosome association requires TDRD3, which directly interacts with Top3beta and is present in animals but not bacteria or yeast. PMID: 27257063
3. The binding specificity and affinity of the Tudor domains of TDRD3, SMN and SPF30 proteins were characterized quantitatively. PMID: 22363433
4. The TDRD3 is an effector molecule that promotes transcription by binding methylarginine marks on histone tails. PMID: 21172665
5. Tudor domain of TDRD3 was required for its recruitment to cytoplasmic stress granules. PMID: 18632687
6. propose a contribution of Tdrd3 to FMRP-mediated translational repression and suggest that the loss of the FMRP-Tdrd3 interaction caused by the I304N mutation might contribute to the pathogenesis of Fragile X syndrome PMID: 18664458
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亞細胞定位：

Cytoplasm. Nucleus.
組織特異性：

Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
數據庫鏈接：

HGNC: 20612

OMIM: 614392

KEGG: hsa:81550

STRING: 9606.ENSP00000440190

UniGene: Hs.525061

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