TCTN2 Antibody

說明書

產品詳情

Uniprot No.：

Q96GX1
基因名：

TCTN2
別名：

C12orf38 antibody; FLJ12975 antibody; MKS8 antibody; OTTHUMP00000239215 antibody; OTTHUMP00000239216 antibody; Tctn2 antibody; TECT2 antibody; TECT2_HUMAN antibody; Tectonic family member 2 antibody; Tectonic-2 antibody
反應種屬：

Human,Mouse,Rat
免疫原：

Human TCTN2
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,IF,IP
Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
Immunoprecipitation (IP) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction.
基因功能參考文獻：
1. a truncating mutation in TCTN2 linked to Meckel Gruber syndrome was shown. PMID: 21462283
2. Network building strategy led to the proposal of candidates for new ciliopathy disease genes, leading to the identification of the first human mutations in the Nephronophthisis gene Ataxin10 (ATXN10) and Joubert syndrome gene Tectonic2 (TCTN2). PMID: 21565611
相關疾病：

Meckel syndrome 8 (MKS8); Joubert syndrome 24 (JBTS24)
亞細胞定位：

Membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton, cilium basal body.
蛋白家族：

Tectonic family
數據庫鏈接：

HGNC: 25774

OMIM: 613846

KEGG: hsa:79867

STRING: 9606.ENSP00000304941

UniGene: Hs.167165

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