TCN1 Antibody

說(shuō)明書(shū)

中文名稱：

TCN1兔多克隆抗體
貨號(hào)：

CSB-PA023317LA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA023317LA01HU at dilution of 1:100
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) TCN1 Polyclonal antibody
Uniprot No.：

P20061
基因名：

TCN1
別名：

Haptocorin antibody; Haptocorrin antibody; HC antibody; OTTHUMP00000235879 antibody; TC 1 antibody; TC I antibody; TC-1 antibody; TC1 antibody; TCI antibody; TCN 1 antibody; TCN1 antibody; TCO1_HUMAN antibody; Transcobalamin 1 antibody; Transcobalamin I antibody; Transcobalamin-1 antibody; Transcobalamin1 antibody; TranscobalaminI antibody; Vitamin B12 binding protein antibody; Vitamin B12 binding protein R binder family antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Transcobalamin-1 protein (24-433AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，TCN1 Antibody (CSB-PA023317LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于TCN1 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA023317LB01HU	TCN1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA023317LC01HU	TCN1 Antibody, FITC conjugated
Biotin	CSB-PA023317LD01HU	TCN1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach.
基因功能參考文獻(xiàn)：
1. Higher placental TC protein abundance was associated with higher cord blood vitamin B12 concentrations, suggesting a potential role in vitamin B12 transport to the fetus. PMID: 27577703
2. The variant rs526934 from the TCN1 gene was associated with an increased risk of developing gastric cancer. PMID: 26959381
3. Levels of holotranscobalamin are decreased patients with cobalamin deficiency. PMID: 24057896
4. Structural basis for universal corrinoid recognition by the cobalamin transport protein haptocorrin. PMID: 23846701
5. TCN1 gene expression implicates disease progression in patient with middle ear cholesteatoma. PMID: 23670528
6. comparison of human and rainbow trout cobalamin-binding protein PMID: 22872637
7. Elevated concentrations of B(12) found in autoimmune lymphoproliferative syndrome patients were due to increased lymphocyte expression of haptocorrin. PMID: 22306884
8. Stromal expression of KRT15, TCN1, and HOXB13 was significantly correlated with tumor grade, stromal hypercellularity, mitotic activity and microscopic borders. PMID: 21574054
9. two novel mutations, each causing a premature stop codon - a genetic basis for TC I deficiency PMID: 19686235
10. Comparative analysis of cobalamin binding kinetics PMID: 11788601
11. No association between the MTHFR A1298C and transcobalamin C776G genetic polymorphisms and hyperhomocysteinemia in thrombotic disease. PMID: 12590948
12. interactions of COBALAMIN BINDING proteins with a number of ligands PMID: 17487979
13. Maternal folate-related polymorphisms studied here (CBS, MTR, RFC-1, and TC) have no influence on trisomy 21 susceptibility in subjects of Brazilian population.v PMID: 19729796
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亞細(xì)胞定位：

Secreted.
蛋白家族：

Eukaryotic cobalamin transport proteins family
組織特異性：

Produced by the salivary glands of the oral cavity, in response to ingestion of food. Major constituent of secondary granules in neutrophils.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 11652

OMIM: 189905

KEGG: hsa:6947

STRING: 9606.ENSP00000257264

UniGene: Hs.2012

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