TBC1D7 Antibody, FITC conjugated

說明書

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) TBC1D7 Polyclonal antibody
Uniprot No.：

Q9P0N9
基因名：

TBC1D7
別名：

TBC1D7 antibody; TBC7 antibody; HSPC239 antibody; TBC1 domain family member 7 antibody; Cell migration-inducing protein 23 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human TBC1 domain family member 7 protein (1-293AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.
相關(guān)疾病：

Macrocephaly/megalencephaly syndrome, autosomal recessive (MGCPH)
亞細(xì)胞定位：

Cytoplasmic vesicle. Note=Localizes in the cytoplasmic vesicles of the endomembrane in association with TSC1-TSC2 complex.
組織特異性：

Highly expressed in heart, and slightly in kidney, liver and placenta.
數(shù)據(jù)庫鏈接：

HGNC: 21066

OMIM: 248000

KEGG: hsa:107080638

STRING: 9606.ENSP00000348813

UniGene: Hs.484678

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