TAS2R14 Antibody

文獻引用 (1) 說明書

中文名稱：

TAS2R14兔多克隆抗體
貨號：

CSB-PA868362LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA868362LA01HU at dilution of 1:100
其他：

產品詳情
產品評價
引用文獻
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TAS2R14 Polyclonal antibody
Uniprot No.：

Q9NYV8
基因名：

TAS2R14
別名：

TAS2R14; Taste receptor type 2 member 14; T2R14; Taste receptor family B member 1; TRB1
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Taste receptor type 2 member 14 protein (283-317AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，TAS2R14 Antibody (CSB-PA868362LA01HU)，的標記方式是Non-conjugated。對于TAS2R14 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA868362LB01HU	TAS2R14 Antibody, HRP conjugated	ELISA
FITC	CSB-PA868362LC01HU	TAS2R14 Antibody, FITC conjugated
Biotin	CSB-PA868362LD01HU	TAS2R14 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

引用文獻

Functional Alteration and Differential Expression of the Bitter Taste Receptor T2R38 in Human Paranasal Sinus in Patients with Chronic Rhinosinusitis K Takemoto,International journal of molecular sciences,2023

產品評價

靶點詳情

功能：

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.
基因功能參考文獻：
1. We observed that the homozygous carriers of the (G) allele of the TAS2R14-rs3741843 polymorphism showed a decreased sperm progressive motility compared to heterozygotes and (A) homozygotes. PMID: 29040583
2. These data indicate that, unlike in taste cells, TAS2Rs couple to the prevalent G proteins, Galphai1, Galphai2, and Galphai3, with no evidence for functional coupling to Galphagust. PMID: 28145731
3. Heterologously expressed T2R14 responds to multiple flavones. These flavones also activate T2R14-driven calcium signals in primary cells that activate nitric oxide production to increase ciliary beating and mucociliary clearance. PMID: 28373278
4. Thus the beta2AR acts as a double-edged sword: increasing TAS2R14 cell surface expression, but when activated by beta-agonist, partially offsetting the expression phenotype by direct receptor:receptor desensitization of TAS2R14 function. PMID: 27342779
5. Probing the Binding Pocket of the Broadly Tuned Human Bitter Taste Receptor TAS2R14 by Chemical Modification of Cognate Agonists. PMID: 26825540
6. TAS2R14 and TAS2R39 were activated by isoflavones and other isoflavonoids. PMID: 21942422
7. These results point to a potential route of action by which components of Hoodia might influence appetite control; the natural taste receptor antagonist was identified for further studies as an appetite suppressant. PMID: 20930049
8. no evidence of statistically significant associations between polymorphisms in the TAS2R14 gene and colon cancer risk PMID: 20534144
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亞細胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor T2R family
組織特異性：

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in testis.
數據庫鏈接：

HGNC: 14920

OMIM: 604790

KEGG: hsa:50840

STRING: 9606.ENSP00000441949

UniGene: Hs.679406

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