STXBP5 Antibody, FITC conjugated
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中文名稱：STXBP5兔多克隆抗體, FITC偶聯
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貨號：CSB-PA722568LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) STXBP5 Polyclonal antibody
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Uniprot No.：
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基因名：STXBP5
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別名：STXBP5 antibody; LLGL3 antibody; Syntaxin-binding protein 5 antibody; Lethal(2) giant larvae protein homolog 3 antibody; Tomosyn-1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Syntaxin-binding protein 5 protein (515-610AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding.
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基因功能參考文獻：
- Glucose-dependent de-SUMOylation of tomosyn1 at K298 releases syntaxin1A and controls the amplification of exocytosis in concert with a recently-identified tomosyn1-interacting partner; the Ca(2+)-binding protein secretagogin, which dissociates from tomosyn1 in response to Ca(2+)-raising stimuli and is required for insulin granule trafficking and exocytosis downstream of Ca(2+) influx. PMID: 28325894
- Using CRISPR/Cas9 genome editing, identified a human nonsynonymous SNP rs1039084 in the STXBP5 locus as a causal variant for a decreased thrombotic phenotype. PMID: 28062498
- Genetic variations in STXBP5 and CLEC4M are associated with VWF level variation in type 1, but not in type 2 von Willebrand disease. PMID: 25832887
- STXBP5 is required for normal arterial hemostasis, due to its contributions to platelet granule cargo packaging and secretion PMID: 25244094
- STXBP5 inhibits endothelial exocytosis and promotes platelet secretion PMID: 25244095
- Identify 3 loci associated with circulating tPA levels, the PLAT region, STXBP5, and STX2. Functional studies implicate a novel role for STXBP5 and STX2 in regulating tPA release. PMID: 24578379
- Genetic variation in STXBP5 is associated with bleeding phenotype in female type 1 von Willebrand Disease patients. PMID: 22792389
- Genetic variation in STXBP5 gene is associated with venous thrombosis. PMID: 21163921
- multiple domains outside the R-SNARE of tomosyn are critical to the efficacy of inhibition by tomosyn on exocytotic secretion PMID: 21330375
- Genetic variability in STXBP5 and STX2 affects both VWF concentration and activity in young individuals with premature arterial thrombosis. PMID: 21156930
- Characterization of a related rat protein PMID: 9620695
- Characterization of a related rat gene PMID: 10066450
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亞細胞定位：Cytoplasm. Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cell junction, synapse.
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蛋白家族：WD repeat L(2)GL family
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數據庫鏈接：
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