STK38 Antibody
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中文名稱：STK38兔多克隆抗體
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貨號：CSB-PA614885ESR1HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA614885ESR1HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) STK38 Polyclonal antibody
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Uniprot No.：
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基因名：STK38
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別名：NDR 1 antibody; NDR antibody; Ndr Ser/Thr kinase-like protein antibody; NDR1 antibody; NDR1 protein kinase antibody; Nuclear Dbf2 related kinase 1 antibody; nuclear Dbf2-related 1 antibody; Nuclear Dbf2-related kinase 1 antibody; Nuclear Dbf2-related protein antibody; Serine/threonine protein kinase 38 antibody; Serine/threonine-protein kinase 38 antibody; STK 38 antibody; STK38 antibody; STK38_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Serine/threonine-protein kinase 38 protein (1-200AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2.
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基因功能參考文獻：
- Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop. PMID: 30018336
- Study provides evidence for an inhibitory role of SOCS2 in TNFalpha induced NF-kappa B activation, identifies NDR1 as a novel substrate of SOCS2, and demonstrates that SOCS2 and TNFalpha induced NF-kappa B signaling are linked through NDR1. PMID: 28216640
- Data show that STK38 supports Ras-driven transformation through promoting detachment-induced autophagy. PMID: 27283898
- a novel and intimate link between the protein kinase NDR1 and TGFbeta signaling PMID: 23840619
- Data establish STK38 as a conserved regulator of autophagy in human cells and flies. PMID: 26387716
- PLK1-mediated phosphorylation protects the binding of Mob1 to NDR1 and subsequent NDR1 activation PMID: 26057687
- STK38-mediated phosphorylation of CDC25A at Ser-76 and the subsequent degradation of CDC25A are required to promote DNA damage-induced G2/M checkpoint activation. PMID: 25936524
- STK38 regulates MYC protein stability and turnover in a kinase activity-dependent manner. STK38 kinase inactivation abrogates apoptosis following B-cell receptor activation, whereas its silencing significantly decreases MYC levels and increases apoptosis. PMID: 23178486
- cyclin D1 has a role in promoting cell cycle progression by enhancing NDR1/2 kinase activity independent of Cdk4 PMID: 23897809
- 17-allylamino-17-demethoxygeldanamycin down-regulates STK38, modulating radiosensitivity. PMID: 23886587
- Findings suggest a function of NDR1, which may regulate NF-kappaB activation by its kinase activity. PMID: 22674419
- GSK-3beta inhibits full activation of STK38, and STK38 activation is required to prevent cell death in response to oxidative stress PMID: 22142472
- Findings show a biological role for MICAL-1 in apoptosis and define a novel negative regulatory mechanism of MST-NDR signaling. PMID: 21730291
- These findings establish a novel MST3-NDR-p21 axis as an important regulator of G(1)/S progression of mammalian cells. PMID: 21262772
- Data indicate that human MOB2 is a negative regulator of human NDR kinases in biochemical and biological settings. PMID: 20624913
- NDR1 and NDR2 serine-threonine kinases are regulated by mob proteins PMID: 15067004
- an insert within the catalytic domain between subdomains VII and VIII is autoinhibitory, and the binding of human MOB1 to the N-terminal domain of NDR induces the release of this autoinhibition. PMID: 15197186
- The NDR1 and NDR2 kinases were incorporated into HIV-1 particles and were cleaved by the HIV-1 protease. PMID: 15582665
- In vivo activation of human NDR by membrane-bound hMOBs is dependent on their interaction and occurs solely at the membrane. PMID: 16135814
- These data indicate that NDR-driven centrosome duplication requires Cdk2 activity and that Cdk2-induced centrosome amplification is affected upon reduction of NDR activity. PMID: 17317633
- phosphorylation of MOB1 at Thr74 by MST2 is essential to make a complex of MOB1, MST2 and NDR1, and to fully activate NDR1 PMID: 18362890
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亞細胞定位：Nucleus. Cytoplasm.
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蛋白家族：Protein kinase superfamily, AGC Ser/Thr protein kinase family
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組織特異性：Ubiquitously expressed with highest levels observed in peripheral blood leukocytes.
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數據庫鏈接：
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