STAG1 Antibody

說明書

中文名稱：

STAG1兔多克隆抗體
貨號：

CSB-PA022785GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q8WVM7
基因名：

STAG1
別名：

Cohesin subunit SA 1 antibody; Cohesin subunit SA-1 antibody; Cohesin Subunit SA1 antibody; Nuclear protein stromal antigen 1 antibody; SA 1 antibody; SCC 3 homolog 1 antibody; Scc3 antibody; SCC3 homolog 1 antibody; STAG 1 antibody; stag1 antibody; STAG1_HUMAN antibody; Stromal antigen 1 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human STAG1
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
基因功能參考文獻：
1. The SNP but not wild-type had profound alterations in SA-1 expression with miR-29b inhibitor. PMID: 29471289
2. Here the authors demonstrate that the most frequently mutated subunit of the cohesin complex, STAG2, displays a strong synthetic lethal interaction with its paralog STAG1. Mechanistically, STAG1 loss abrogates sister chromatid cohesion in STAG2 mutated but not in wild-type cells leading to mitotic catastrophe, defective cell division and apoptosis. PMID: 28691904
3. This first series reporting the phenotype ascribed to mutation in STAG1 highlights the importance of data sharing in the field of rare disorders. PMID: 28119487
4. Data indicate that cohesin subunit SA-1 (STAG1) is a promising therapeutic target in cancers with inactivating alterations of cohesin subunit SA-2 (STAG2). PMID: 28430577
5. There is LOH at STAG1 and STAG2 loci in oral squamous cell carcinoma (OSCC), but OSCC and NM showed similar transcriptional levels of STAG1, STAG2, and PDS5B. PMID: 27341316
6. Data support the hypothesis that CTCF and cohesin SA-1 have multiple roles in the regulation of gene expression during erythropoiesis. PMID: 27219007
7. TRF1 tethers SA1 within telomeric regions that SA1 transiently interacts with. SA1 and TRF1 together form longer DNA-DNA pairing tracts than with TRF1 alone, as revealed by atomic force microscopy imaging PMID: 27298259
8. Nuclear import and export signals of human cohesins SA1/STAG1 and SA2/STAG2 expressed in Saccharomyces cerevisiae. PMID: 22715410
9. Mutations in STAG1 is associated with acute myeloid leukemia. PMID: 24335498
10. cohesin-SA1 and cohesin-SA2 participate in the DNA damage response PMID: 24324008
11. Rad21 binds to SA proteins through two SA-binding motifs on Rad21. PMID: 23874961
12. STAG1, a novel transcriptional target for p53, mediates p53-dependent apoptosis, and might be a good candidate for next-generation gene therapy in cancer. PMID: 15361841
13. STAG1 (Scc3/SA1) subunit of cohesin interacts with the CCTC-binding factor CTCF bound to the c-myc insulator element. PMID: 18550811
14. cohesin(SA1) and cohesin(SA2) are differentially required for telomere and centromere cohesion, respectively. PMID: 19822671
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相關疾病：

Mental retardation, autosomal dominant 47 (MRD47)
亞細胞定位：

Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation.
蛋白家族：

SCC3 family
數據庫鏈接：

HGNC: 11354

OMIM: 604358

KEGG: hsa:10274

STRING: 9606.ENSP00000372689

UniGene: Hs.412586

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