STAC3 Antibody, Biotin conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) STAC3 Polyclonal antibody
Uniprot No.：

Q96MF2
基因名：

STAC3
別名：

MGC2793 antibody; SH3 and cysteine rich domain 3 antibody; SH3 and cysteine rich domain-containing protein 3 antibody; SH3 and cysteine-rich domain-containing protein 3 antibody; stac3 antibody; STAC3_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human SH3 and cysteine-rich domain-containing protein 3 protein (1-253AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels. Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane. Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membrane. Slows down the inactivation rate of the calcium channel CACNA1C.
基因功能參考文獻：
1. STAC3 mutation is associated with overlapping features of Carey-Fineman-Ziter syndrome and Moebius syndrome. PMID: 28777491
2. A mutation in human STAC3 is the genetic basis of the debilitating Native American myopathy. PMID: 23736855
相關疾病：

Native American myopathy (NAM)
亞細胞定位：

Cytoplasm. Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cell membrane, sarcolemma, T-tubule.
數據庫鏈接：

HGNC: 28423

OMIM: 255995

KEGG: hsa:246329

STRING: 9606.ENSP00000329200

UniGene: Hs.417595

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