ST6GALNAC2 Antibody

說(shuō)明書(shū)

中文名稱：

ST6GALNAC2兔多克隆抗體
貨號(hào)：

CSB-PA883452LA01HU
規(guī)格：

￥440
圖片：
Western blot
All lanes: ST6GALNAC2 antibody at 8μg/ml + MCF-7 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 42 kDa
Observed band size: 42 kDa
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) ST6GALNAC2 Polyclonal antibody
Uniprot No.：

Q9UJ37
基因名：

ST6GALNAC2
別名：

ST6GALNAC2 antibody; SIAT7B antibody; SIATL1 antibody; STHMAlpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 antibody; EC 2.4.99.3 antibody; GalNAc alpha-2,6-sialyltransferase II antibody; ST6GalNAc II antibody; ST6GalNAcII antibody; SThM antibody; Sialyltransferase 7B antibody; SIAT7-B antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 protein (101-374AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，ST6GALNAC2 Antibody (CSB-PA883452LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于ST6GALNAC2 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA883452LB01HU	ST6GALNAC2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA883452LC01HU	ST6GALNAC2 Antibody, FITC conjugated
Biotin	CSB-PA883452LD01HU	ST6GALNAC2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins.
基因功能參考文獻(xiàn)：
1. MicroRNAs miR-135b and miR-182 may reverse the resistance to 5-fluorouracil (5-FU) in colorectal cancer (CRC) cells by targeting ST6GALNAC2 via PI3K/AKT pathway, which render potential chemotherapy targets for the treatment of CRC. PMID: 28767179
2. miR-182/-135b/ST6GALNAC2/PI3K/AKT axis could function as regulator of progression in colorectal cancer PMID: 29030743
3. Study provides evidence that mutations in B3GNT2, B4GALT2, and ST6GALNAC2 underlie aberrant glycosylation, and contribute to the pathogenesis of molecular subsets of colon and other gastrointestinal malignancies. PMID: 27004849
4. Results provide evidence that ST6GalNAcII activated the invasion in follicular thyroid cancer cells through regulating the activity of PI3K/Akt pathway. PMID: 26820593
5. High expression level of ST6GalNAcII is associated with invasive phenotype of breast cancer. PMID: 24756995
6. ST6GalNAc II might be participated in the glycosylation of Axl, and this Axl glycosylation may mediate the tumorigenicity, invasion, and distant metastasis of breast phyllodes tumor cells. PMID: 24961352
7. Results identified the sialyltransferase ST6GalNAc2 as a novel breast cancer metastasis suppressor. PMID: 24520024
8. Il-6 and Il-4 reduced galactosylation of the O-glycan substrate directly via decreased expression of the galactosyltransferase C1GalT1 and, indirectly, via increased expression of the sialyltransferase ST6GalNAc-II PMID: 24398680
9. ST6GalNAc2 is a novel enzyme that regulates leukocyte adhesion under fluid shear PMID: 23548905
10. Expression of the ST6-GalNAcII gene and activity of the CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase were higher in immunoglobulinA1-producing cell lines. PMID: 17418236
11. the ADG haplotype in the ST6GALNAC2 gene is a functional regulatory variant that may contribute to the genetic susceptibility in a subset of patients in whom the desialylation of IgA1 molecules was the main causative pathogenesis of IgAN PMID: 17480010
12. reduced sialylation of serum IgA1 may result from decreased expression of ST6GALNAC2. PMID: 19170967
13. potential genetic interactions of C1GALT1 and ST6GALNAC2 variants influence IgA1 O-glycosylation, disease predisposition, and disease severity, and may contribute to the polygenic nature of IgA nephropathy PMID: 19357720
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亞細(xì)胞定位：

Golgi apparatus membrane; Single-pass type II membrane protein.
蛋白家族：

Glycosyltransferase 29 family
組織特異性：

Expressed in skeletal muscle, heart, kidney, placenta, lung and leukocytes.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 10867

OMIM: 610137

KEGG: hsa:10610

STRING: 9606.ENSP00000225276

UniGene: Hs.592105

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