SRSF7 Antibody
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中文名稱：SRSF7兔多克隆抗體
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貨號：CSB-PA000772
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規格：￥1090
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圖片：
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Western Blot analysis of HuvEc cells using 9G8 Polyclonal Antibody -
Western Blot analysis of HuvEc cells using 9G8 Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：SRSF7
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別名：9G8 antibody; AAG3 antibody; arginine/serine-rich 7 antibody; HSSG1 antibody; RBM37 antibody; Serine/arginine-rich splicing factor 7 antibody; Splicing factor 9G8 antibody; Splicing factor antibody; Splicing factor, arginine/serine rich 7 antibody; SRSF7 antibody; SRSF7_HUMAN antibody; ZCCHC20 antibody; ZCRB2 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthesized peptide derived from the Internal region of Human 9G8.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:40000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific.
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基因功能參考文獻：
- role of SRSF7 in cell proliferation through regulating p21 levels. PMID: 27644562
- SRSF7 expression in cancer cells is regulated by microRNAs: short, non-coding RNAs that bind to 3'UTR of target genes and downregulate their expression. SRSF7 regulate proliferation of renal cancer cells.SRSF7 regulates expression of osteopontin. PMID: 27664584
- Genome-wide identification of CD95 antigen alternative splicing regulators, such as SRSF7, reveals links with iron homeostasis. PMID: 25482508
- Coexpression of Dyrk1A and splicing factor 9G8 leads to their translocation from the nucleus to the cytoplasm and suppresses their ability to regulate tau exon 10 splicing. PMID: 21215488
- Cyclic AMP-dependent protein kinase regulates 9G8-mediated alternative splicing of tau exon 10 PMID: 22677170
- Upregulation of total tau expression (SFRS7-independent) and tau exon 10 splicing (SFRS7-dependent), as shown in this study to be both affected by STOX1A, is known to have implications in neurodegeneration. PMID: 21755018
- These results indicate that 9G8 plays a key role in regulation of exon 10 splicing and imply a pathogenic role in neurodegenerative diseases. PMID: 17137791
- 9G8 was shown to enhance expression of unspliced RNA containing either the Mason-Pfizer monkey virus constitutive transport element PMID: 17513303
- eIF3f mediates restriction of HIV-1 expression through a set of factors that includes eIF3f, the SR protein 9G8, and the cyclin-dependent kinase 11 (CDK11). PMID: 19854136
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亞細胞定位：Nucleus. Cytoplasm.
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蛋白家族：Splicing factor SR family
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組織特異性：Brain, liver, kidney and lung.
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數據庫鏈接：
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