SRSF5 Antibody
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中文名稱：SRSF5兔多克隆抗體
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貨號：CSB-PA050022
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規格：￥1090
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其他：
產品詳情
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Uniprot No.：
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基因名：SRSF5
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別名：arginine/serine-rich 5 antibody; Delayed early protein HRS antibody; Delayed-early protein HRS antibody; HRS antibody; Pre mRNA splicing factor SRP40 antibody; Pre-mRNA-splicing factor SRP40 antibody; Serine and arginine rich splicing factor 5 antibody; Serine/arginine-rich splicing factor 5 antibody; SFRS 5 antibody; SFRS5 antibody; Splicing factor antibody; Splicing factor arginine/serine rich 5 antibody; SRP 40 antibody; SRP40 antibody; SRSF5 antibody; SRSF5_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from the Internal region of Human SRp40.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：IHC, IF, ELISA
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推薦稀釋比：
Application Recommended Dilution IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:20000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.
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基因功能參考文獻：
- Study found that SRSF5 is a novel target of SRSF3. SRSF5 is overexpressed in oral squamous cell carcinoma (OSCC) and functions as an oncogene. Its downregulation in OSCC cell lines slows cell growth, cycle progression, and tumor growth. The expression of SRSF5 seems to controlled by an autoregulation mechanism. PMID: 29857020
- upon glucose intake, the splicing factor SRSF5 is specifically induced through Tip60-mediated acetylation on K125, which antagonizes Smurf1-mediated ubiquitylation. SRSF5 promotes the alternative splicing of CCAR1 to produce CCAR1S proteins, which promote tumor growth by enhancing glucose consumption and acetyl-CoA production. PMID: 29942010
- we show that ErbB3 interacts with the ESCRT-0 subunit Hrs both in the presence and absence of heregulin. This indicates an ESCRT-mediated sorting of ErbB3 to late endosomes and lysosomes, and in line with this we show that impaired ESCRT function leads to an endosomal accumulation of ErbB3. PMID: 28867611
- the up-regulated expression of SRSF 5-7 proteins in LC with much more profound up-regulation in SCLC than in NSCLC and suggest that up-regulation of the SRSFs is related to SCLC proliferation. Moreover, we identified SRSF5 as a novel detection marker for SCLC and pleural metastatic cancer cells. PMID: 27565915
- this study demonstrates that HRS acts as a key component of TLR7 signaling to orchestrate immune and inflammatory responses during EV71 infection PMID: 28854257
- Enhanced SRSF5 Protein Expression Reinforces Lamin A mRNA Production in HeLa Cells and Fibroblasts of Progeria Patients PMID: 26670336
- Suggest that SRp40 might be associated with GRalpha transcripts in systemic lupus erythematosus patients. PMID: 25665148
- We show that changes in alternative splicing of hnRNP A/B, affected by up regulation of SRSF5 (SRp40) or by treatment with C6-ceramide, occur within supraspliceosomes. PMID: 22100336
- Here, the authors report that specific SR proteins, particularly SRp40 and SRp55, promote human immunodeficiency virus type 1 (HIV-1) Gag translation from unspliced (intron-containing) viral RNA. PMID: 20427542
- SRp40 antagonizes ASF/SF2 and SRp55 by competing for binding to certain sites in exon 5, thereby promoting TF exon 5 exclusion, an event unique to asTF biosynthesis. PMID: 19843576
- SRp40 regulates the switch in splicing from production of CREMtau(2)alpha to CREMalpha PMID: 16103121
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亞細胞定位：Nucleus.
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蛋白家族：Splicing factor SR family
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數據庫鏈接：
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