SRP68 Antibody

說明書

產品詳情

Uniprot No.：

Q9UHB9
基因名：

SRP68
別名：

Signal recognition particle 68 antibody; Signal recognition particle 68 kDa antibody; Signal recognition particle 68 kDa protein antibody; signal recognition particle 68kD antibody; Signal recognition particle 68kDa antibody; signal recognition particle subunit SRP68 antibody; SRP 68 antibody; SRP68 antibody; SRP68_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human SRP68
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.
基因功能參考文獻：
1. The essential role of the SRP68-SRP72 interaction in the signal recognition particle-mediated protein translocation PMID: 28369529
2. study presents the crystal structures of the RNA-binding domain of SRP68 (SRP68-RBD) alone and in complex with SRP RNA and SRP19; data provide the structural basis for eukaryote-specific, SRP68-driven RNA remodeling required for protein translocation PMID: 24700861
3. SRP68/72 heterodimers as major nuclear proteins whose binding of histone H4 tail is inhibited by H4R3 methylation. PMID: 23048028
4. The RNA binding domain of SRP68 included residues from positions 52 to 252. Ninety-four amino acids near the C terminus of SRP68 mediated the binding to SRP72 PMID: 16672232
亞細胞定位：

Cytoplasm. Nucleus, nucleolus.
蛋白家族：

SRP68 family
數據庫鏈接：

HGNC: 11302

OMIM: 604858

KEGG: hsa:6730

STRING: 9606.ENSP00000312066

UniGene: Hs.514495

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