SPINT1 Antibody

說明書

中文名稱：

SPINT1兔多克隆抗體
貨號：

CSB-PA022584ESR1HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA022584ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA022584ESR1HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SPINT1 Polyclonal antibody
Uniprot No.：

O43278
基因名：

SPINT1
別名：

HAI 1 antibody; HAI antibody; HAI-1 antibody; HAI1 antibody; Hepatocyte growth factor activator inhibitor type 1 antibody; Kunitz type protease inhibitor 1 antibody; Kunitz-type protease inhibitor 1 antibody; MANSC2 antibody; Serine peptidase inhibitor Kunitz type 1 antibody; SPINT1 antibody; SPIT1_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Kunitz-type protease inhibitor 1 protein (250-529AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14).
基因功能參考文獻：
1. The SPINT1 expression was associated with extrathyroidal invasion, lymphovascular invasion, lymph node metastasis, advanced TNM stage, and a higher risk of recurrence in differentiated thyroid cancer. PMID: 29532159
2. HAI-1 is upregulated in pancreatic intraepithelial neoplasia and broadly expressed in pancreatic ductal adenocarcinoma (PDAC) cells. However, PDAC cases having areas of reduced HAI-1 immunoreactivity may show shorter disease-free survival. PMID: 29202869
3. In this work, KLK14 binding to either hepatocyte growth factor activator inhibitor type-1 (HAI-1) or type-2 (HAI-2) was essayed using homology modeling, molecular dynamic simulations and free-energy calculations through MM/PBSA and MM/GBSA. KLK14 was successfully modeled. PMID: 28817220
4. the cell surface expression of HAI-1 in all viable epidermal layers renders it an effective regulator for matriptase and prostasin PMID: 29438412
5. Data suggest that HAI1, a protease on the surface of colon carcinoma cells, is an MMP7 substrate; proteolysis by MMP7 releases extracellular region as soluble HAI1 (sHAI1); sHAI1 induces cancer cell aggregation; cholesterol sulfate is required for MMP-7--catalyzed generation of sHAI1. (HAI1 = hepatocyte growth factor activator inhibitor type 1; MMP7 = matrix metalloproteinase-7) PMID: 29046355
6. Concomitant presence of TMPRSS13 with HAI-1 mediates phosphorylation of residues in the intracellular domain of the protease, and it coincides with efficient transport of the protease to the cell surface and its subsequent shedding. PMID: 28710277
7. our data illustrated a novel pathway comprising miR-221and miR-222 and hepatocyte growth factor activator inhibitor type 1 in gastric cancer, which is a potential target for future clinical use PMID: 28618968
8. DNA methylation levels in the COASY and SPINT1 promoter regions were considered to potentially be a convenient and useful biomarker for diagnosis of Alzheimer's Disease and Amnestic Mild Cognitive Impairment. PMID: 27992572
9. The structural insights gained here improve our understanding of the regulation of HAI-1 inhibitory activities and point to new approaches for better controlling these activities. PMID: 28348076
10. The present study demonstrated that ovarian cancer cell metastasis and invasion were more dependent on upregulation of matriptase levels than downregulation of HAI1. Matriptase may be a potential adjuvant therapeutic target for inhibiting ovarian cancer invasion and metastasis. PMID: 27356668
11. provide new insight into the interplay between tertiary structure and the inhibitory activity of a multidomain protease inhibitor PMID: 27226587
12. The findings suggest that the oncogenic activity of hepsin arises not only from elevated expression level but also from depletion of HAI-1, events which together trigger gain-of-function activity impacting HGF/MET signalling and epithelial cohesion PMID: 26165838
13. it was found that the recombinant fusion protein uPA17-34-KPI (kunitz-type protease inhibitor ) inhibited the invasion and metastasis of ovarian tumors PMID: 26166362
14. HAI-1 may have a critical role in maintaining normal keratinocyte morphology through regulation of PAR-2-dependent p38 mitogen-activated protein kinase signaling. PMID: 25842366
15. the anti-migratory effects seen via gamma-catenin were driven by the expression of hepatocyte growth factor activator inhibitor Type I (HAI-1 or SPINT-1), an upstream inhibitor of the c-MET signaling pathway. PMID: 25925948
16. Data suggest HAI1 exhibits structural features consistent with classification in MANEC subclass of PAN/apple domain family with unifying features such as two additional disulfide bonds, two extended loop regions, and additional alpha-helical elements. PMID: 25510835
17. Matriptase activity was suppressed by the expression of HAI-1. PMID: 24147538
18. The results of the present study identified HAI-1 as a favorable prognostic marker for prostate cancer and may indicate that HAI-1 could be a therapeutic target for the treatment of this malignancy. PMID: 24659667
19. HAI-1 expression correlates with the differentiation status of colorectal epithelia and could serve as a differentiation marker. PMID: 23979832
20. HAI-1 and HAI-2 influence proliferation and cell fate of NPCs and their expression levels are linked to BMP sign PMID: 23409135
21. Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1 PMID: 23443661
22. It is suggested that HAI-1 may play an important role in the pathogenesis of castration-resistant prostate cancer PMID: 23393351
23. These results suggest that HAI-1 functions as a physiological regulator of HAT by inhibiting its protease activity and proteolytic activation in airway epithelium.(HAI-1) PMID: 22023801
24. we showed for the first time that MT1-MMP activates matriptase through the cleavage of HAI-1 PMID: 22118498
25. These data suggest that matriptase activity can be rapidly inhibited by HAI-1 and other HAI-1-like protease inhibitors and "locked" in an inactive autoactivation intermediate, all of which places matriptase under very tight control. PMID: 22031598
26. HAI-1 and -2 are overexpressed in the liver in cholangiopathies with ductular reactions and are possibly involved in liver fibrosis and hepatic differentiation. PMID: 21898507
27. The data suggested that normal epithelial cells use a dual mechanism involving hepatocyte growth factor activator inhibitor-1 and antithrombin to control matriptase and that the antithrombin-based mechanism is lost in the majority of carcinomas. PMID: 21795523
28. Low HAI-1 is associated with endometrial cancer. PMID: 20715109
29. High-level expression of HAI-1 is retained in the epidermal granular layer. This pattern of expression is retained in most skin disorders. PMID: 21123732
30. Expression of HAI-1 in hepatocellular carcinoma is associated with poor prognosis. HAI-1 may be important in neoplasm progression and a new prognostic factor for hepatocellular carcinoma. PMID: 20213201
31. HAI-1 regulates pulmonary metastasis of the human pancreatic carcinoma cell line SUIT-2 PMID: 21166957
32. results suggest that TMPRSS13 functions as an HGF-converting protease, the activity of which may be regulated by HAI-1 PMID: 20977675
33. the matriptase-prostasin proteolytic cascade is tightly regulated by two mechanisms: 1) prostasin activation temporally coupled to matriptase autoactivation and 2) HAI-1 rapidly inhibiting not only active matriptase but also active prostasin PMID: 20696767
34. Data suggest that over-expression of HAI-1 in SW620 cells has weak effect on cell growth in vitro, but can significantly inhibit cell migration/motility. PMID: 16044910
35. hepatocyte growth factor activator inhibitor-1B (new isoform) has roles in various physiological and pathological processes PMID: 12815039
36. 1 serine protease inhibitor genotype is a significant risk factor for chronic obstructive pulmonary disease. PMID: 15994391
37. HAI-1B is a potential physiological regulator of prostasin function PMID: 16103126
38. The expressions of SNC19/matriptase and its inhibitor HAI-1 are decreased in gastrointestinal cancer tissues PMID: 16273651
39. results show that dysregulation of the matriptase/HAI-1 mRNA ratio occurs early during colorectal cancer carcinogenesis PMID: 16820046
40. Addition of HAI1 blocked the proteolytic activation of STP14 at the cell surface of peritoneal macrophages. PMID: 17389401
41. Prostate cancer cells, after loss of HAI-1, had a significantly increased in vitro invasiveness together with an increase in cellular motility. PMID: 17786295
42. analysis of the regulation of matriptase and HAI-1 with an emphasis on the molecular mechanisms governing its zymogen activation, inhibition by HAI-1, and ectodomain shedding [review] PMID: 17981575
43. Unlike HAI-1 and matriptase, HAI-2 expression is detected in non-epithelial cells of brain and lymph nodes, suggesting that HAI-2 may also be involved in inhibition of serine proteases other than matriptase PMID: 18713750
44. tissue microenvironment regulates the cell surface expression of HAI-1, and thereby may regulate proteolysis and processing of bioactive molecules on the cellular surface PMID: 18769935
45. HAI-1 expression levels were significantly higher in all proliferative prostate diseases and seems to be a marker of prostate epithelial cell proliferation PMID: 18813126
46. HAI-1 and HAI-2 may possibly be therapeutic target for treatment approaches in ovarian cancer. PMID: 19148468
47. Expression of hepatocyte growth factor activator inhibitor type 1 in bronchial epithelial cells are altered by tissue injury to bronchi. PMID: 19222607
48. interactions between HAI-1/SPINT1 and membrane-bound serine proteinases contribute to transcriptional and functional changes involved in EMT in certain carcinoma cells. PMID: 19223533
49. Data suggest that the cellular location of matriptase activation and inhibition, and the secretory route for matriptase-HAI-1 complex may vary along with the functional divergence of different epithelial cells. PMID: 19535514
50. The disease-free and overall survival rates of patients exhibiting high HAI-1 expression were significantly higher than those of patients exhibiting low HAI-1 expression in cervix cancer. PMID: 19578736
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亞細胞定位：

Secreted.
數據庫鏈接：

HGNC: 11246

OMIM: 605123

KEGG: hsa:6692

STRING: 9606.ENSP00000342098

UniGene: Hs.233950

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