SPCS1 Antibody

說明書

產品詳情

Uniprot No.：

Q9Y6A9
基因名：

SPCS1
別名：

HSPC033 antibody; Microsomal signal peptidase 12 kDa subunit antibody; OTTHUMP00000206959 antibody; signal peptidase 12kDa antibody; Signal peptidase complex subunit 1 antibody; signal peptidase complex subunit 1 homolog (S. cerevisiae) antibody; SPase 12 kDa subunit antibody; SPC1 antibody; SPC12 antibody; SPCS1 antibody; SPCS1_HUMAN antibody; YJR010C-A antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human SPCS1
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.; (Microbial infection) Required for the post-translational processing of proteins involved in virion assembly and secretion from flaviviruses such as West Nile virus (WNV), Japanese encephalitis virus (JEV), Dengue virus type 2 (DENV-2), Yellow Fever virus (YFV), Zika virus (ZIKV) and hepatitis C virus (HCV). Plays a key role in the post-translational processing of flaviviral structural proteins prM, E, and NS1. In HCV, it is involved in virion assembly where it promotes the interaction between HCV virus proteins NS2 and E2.
基因功能參考文獻：
1. the results demonstrate that SPCS1 affects viral replication by interacting with NS2B, thereby influencing the posttranslational processing of Japanese Encephalitis Virus proteins and the assembly of virions. PMID: 29593046
2. SPCS1 plays a key role in the formation of the membrane-associated NS2-E2 complex via its interaction with NS2 and E2, which leads to a coordinating interaction between the structural and non-structural proteins PMID: 24009510
亞細胞定位：

Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
蛋白家族：

SPCS1 family
數據庫鏈接：

HGNC: 23401

OMIM: 610358

KEGG: hsa:28972

STRING: 9606.ENSP00000233025

UniGene: Hs.11125

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