SPAG8 Antibody

中文名稱：

SPAG8兔多克隆抗體
貨號：

CSB-PA858730LA01HU
規(guī)格：

￥440
圖片：
Immunofluorescence staining of PC-3 cells with CSB-PA858730LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) SPAG8 Polyclonal antibody
Uniprot No.：

Q99932
基因名：

SPAG8
別名：

BS 84 antibody; CILD28 antibody; HSD 1 antibody; HSD-1 antibody; HSD1 antibody; hSMP1 antibody; MGC26201 antibody; MH SPAG8 antibody; OTTHUMP00000021352 antibody; OTTMUSP00000032209 antibody; SMP-1 antibody; SMP1 antibody; SPAG3 antibody; SPAG8 antibody; SPAG8_HUMAN antibody; Sperm associated antigen 8 antibody; Sperm associated antigen 8 like protein antibody; Sperm membrane protein 1 antibody; Sperm membrane protein BS-84 antibody; Sperm-associated antigen 8 antibody; Testicular tissue protein Li 177 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Sperm-associated antigen 8 protein (236-409AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，SPAG8 Antibody (CSB-PA858730LA01HU)，的標(biāo)記方式是Non-conjugated。對于SPAG8 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA858730LB01HU	SPAG8 Antibody, HRP conjugated	ELISA
FITC	CSB-PA858730LC01HU	SPAG8 Antibody, FITC conjugated
Biotin	CSB-PA858730LD01HU	SPAG8 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau. Involved in the acrosome reaction and in binding of sperm to the zona pellucida. Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9.
基因功能參考文獻(xiàn)：
1. Results indicate that SPAG8 acts as a regulator of ACT and plays an important role in CREM-ACT-mediated gene transcription during spermatogenesis. PMID: 20488182
2. The antibody of this recombinant protein inhibits the mouse acrosome reaction and prmits mouse sperm-zona pellucida binding. PMID: 17187156
3. Sperm associated antigen 8 might be involved in the regulation of cell cycle by changing the phosphorylation level of Tyr15 on CDC2 Protein Kinase. PMID: 19548270
亞細(xì)胞定位：

Cytoplasm. Nucleus. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasm, cytoskeleton, microtubule organizing center. Cytoplasm, cytoskeleton, spindle.
蛋白家族：

SPAG8 family
組織特異性：

Expressed in testis (germ cells), but not in liver, kidney, prostate and small intestine.
數(shù)據(jù)庫鏈接：

HGNC: 14105

OMIM: 605731

KEGG: hsa:26206

STRING: 9606.ENSP00000340982

UniGene: Hs.256747

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